The association of periodontal disease with kidney function decline: a longitudinal retrospective analysis of the MrOS dental study

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Vanessa GrubbsOsteoporotic Fractures in Men (MrOS) Study Research Group

Abstract

Identifying modifiable risk factors for chronic kidney disease (CKD) is essential for reducing its burden. Periodontal disease is common, modifiable and has been implicated as a novel potential CKD risk factor, but evidence of its association with kidney function decline over time is limited. In a longitudinal retrospective cohort of 761 elderly men with preserved kidney function [estimated glomerular filtration rate > 60 mL/min/1.73 m(2) using a calibrated creatinine and cystatin C (eGFRcr-cys) equation] at baseline, we performed multivariable Poisson's regression to examine the association of severe periodontal disease with incident CKD, defined as incident eGFRcr-cys <60 mL/min/1.73 m(2) and rapid (>5% annualized) eGFRcr-cys decline. Severe periodontal disease was defined in two ways: (i) ≥5 mm proximal attachment loss in 30% of teeth examined (European Workshop in Periodontology Group C, European Workshop); and (ii) 2+ interproximal sites with attachment loss ≥6 mm and 1+ interproximal sites with probing depth ≥5 mm (Centers for Disease Control/American Academy of Periodontology, CDC/AAP). At baseline, the mean age was 73.4 (SD 4.8) years, the median eGFRcr-cys was 82.4 mL/min/1.73 m(2), and 35.5 and 25.4% of participants h...Continue Reading

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Citations

May 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vera Krane, Christoph Wanner
Oct 23, 2018·Journal of Periodontal Research·Masanori IwasakiKozo Matsubayashi
Jan 24, 2018·Nephrology·Kostas KapellasUNKNOWN Perio-CKD collaboration
Apr 25, 2020·Journal of Periodontology·J Max Goodson
Apr 18, 2019·Journal of Clinical Periodontology·Attawood LertpimonchaiAmmarin Thakkinstian
Jul 25, 2019·International Journal of Molecular Sciences·Mineaki KitamuraHideki Sakai
Feb 8, 2019·Critical Reviews in Microbiology·Aditi Chopra, Karthik Sivaraman
Oct 24, 2019·Free Radical Biology & Medicine·Opeyemi Stella AdemowoIrundika H K Dias
Dec 29, 2020·Journal of Clinical Periodontology·Praveen SharmaThomas Dietrich
Feb 23, 2021·Journal of Nephrology·Keita HiranoDaiki Kobayashi

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