The association of plasma adiponectin level with carotid arterial stiffness

Metabolism: Clinical and Experimental
Takahiro ArakiYoshiki Nishizawa

Abstract

Adiponectin plays important roles in protecting against both insulin resistance and the development of atherosclerosis. The aim of the present study was to investigate the clinical impact of plasma adiponectin on arterial stiffness, a functional property of atherosclerosis, in type 2 diabetic and nondiabetic subjects. We evaluated plasma adiponectin levels and stiffness index beta for the common carotid artery assessed by ultrasound using a phase-locked echo-tracking system for 98 type 2 diabetic subjects and 116 nondiabetic subjects as controls. Plasma adiponectin levels were significantly lower in the diabetic than in the nondiabetic group. The stiffness index beta was significantly higher in the diabetic than in the nondiabetic group. Plasma adiponectin level was significantly correlated with stiffness index beta in the group of all subjects (r=-0.189, P=.006) and the nondiabetic group (r=-0.187, P=.045), but not in the diabetic group (r=0.045, P=.665). On multiple regression analysis, plasma adiponectin level was found to be a significant independent contributor to stiffness index beta in the group of all subjects (beta=-0.232, P=.020) and the nondiabetic group (beta=-0.337, P=.016), but not in the diabetic group. In conclu...Continue Reading

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Citations

Aug 26, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E M UrbinaL M Dolan
Mar 11, 2010·Menopause : the Journal of the North American Menopause Society·Jong Suk ParkHyun Chul Lee
Oct 12, 2011·Journal of Atherosclerosis and Thrombosis·Jong Suk ParkHyun Chul Lee
Jun 2, 2015·Vascular Pharmacology·Marta Gil-OrtegaMaría S Fernández-Alfonso
Jan 17, 2007·Clinical Endocrinology·Katsuhito MoriYoshiki Nishizawa
Jul 15, 2006·Metabolism: Clinical and Experimental·Takahiro ArakiYoshiki Nishizawa
Sep 6, 2014·American Journal of Hypertension·Peter WohlfahrtFrancisco Lopez-Jimenez
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Stefan GustafssonErik Ingelsson
Mar 8, 2016·Journal of Atherosclerosis and Thrombosis·Hirokazu MorigamiMasaaki Inaba
Jul 3, 2021·Medicina·Ioana ParaMihai D Porojan

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