The association of serum creatinine and estimated glomerular filtration rate variability with diabetic retinopathy in Asians with type 2 diabetes: A nested case-control study

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Xiao ZhangSu Chi Lim

Abstract

Fluctuation of kidney function may signify intra-glomerular microvascular hemodynamic instability. We aim to examine the association of long-term serum creatinine and estimated glomerular filtration rate variability with diabetic retinopathy. We included type 2 diabetes mellitus patients who attended the Diabetes Centre in 2011-2014 and were followed up (median = 3.2 years). Digital colour fundus photographs were assessed for diabetic retinopathy at follow-up. Diabetic retinopathy severity was categorized into non-proliferative diabetic retinopathy and proliferative diabetic retinopathy. We conducted a nested case-control study involving 177 diabetic retinopathy (118 non-proliferative diabetic retinopathy, 50 proliferative diabetic retinopathy) and 327 age- and gender-matched non-diabetic retinopathy. Serum creatinine measured before follow-up visit was obtained (⩾3 readings/patient). Variability was calculated as intra-individual standard deviation/√ n/( n - 1). Diabetic retinopathy have higher adjusted-serum creatinine-standard deviation than non-diabetic retinopathy [9.1 (4.9-21.6) vs 5.4 (3.4-10.1) µM, p < 0.001]. After multivariable adjustment, adjusted-serum creatinine-standard deviation was associated with diabetic retin...Continue Reading

References

Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Jun 10, 2006·Stroke; a Journal of Cerebral Circulation·Ji-Guang WangMichel Safar
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Aug 3, 2012·Kidney International·Ziyad Al-AlyAnn M O'Hare
Sep 12, 2012·Archives of Ophthalmology·Juan E GrunwaldUNKNOWN CRIC Study Group
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Feb 18, 2016·PloS One·Antonio Rodríguez-PoncelasGabriel Coll-de Tuero

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Citations

Nov 24, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P Larrañaga-FragosoH Zambarakji
Jul 11, 2019·Archives of Physiology and Biochemistry·Shizhe GuoJiwu Chen
Jul 3, 2021·Journal of Personalized Medicine·Marta Wysocka-MincewiczAndrzej Olechowski

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

STATA

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