PMID: 26765066Jan 15, 2016Paper

The association of serum parathyriod hormone and calcium levels with primary aldosteronism: a meta-analysis

Minerva endocrinologica
Yiyun Zhang, Bo Feng

Abstract

Primary aldosteronism (PA) is a major cause of secondary hypertension, and is strongly associated with high morbidity and mortality of cardiovascular diseases. Aldosterone excess may influence mineral homeostasis through higher urinary calcium (Ca) excretion, reduce calcium plasma levels, and lead to secondary increase of parathyriod hormone (PTH). The purpose of the present study is to clarify the association of serum PTH and Ca levels with PA in a meta-analysis. We identified relevant studies by searching Pubmed, OVID and Sciencedirect (up to September 2014). Studies that met our predefined criteria were included. Six articles from 8 case-control studies were included, involving 748 subjects. Overall, the pooled analyses indicated that subjects with PA had significantly higher serum PTH concentrations and lower Ca levels than controls with essential hypertension (EH) (PTH: SMD=1.146, 95% CI=[0.774,1.518]; Ca: SMD=-0.698, 95% CI=[-1.102,-0.294]). Subgroup analysis stratified by type of Ca measurement found a similar pattern by spectrophotometry (SMD=-1.078, 95% CI=[-1.532,-0.623]), but not by ion selective electrode (SMD=-0.248, 95%CI=[-0.810,0.315]). Sensitivity analysis showed that the results were not materially changed in ...Continue Reading

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