The association of serum uric acid levels with outcomes following percutaneous coronary intervention.

Journal of Interventional Cardiology
Daniel B SpoonCharanjit S Rihal

Abstract

Serum uric acid may serve as a marker for the activation of oxidative stress and may therefore be a marker for subsequent cardiovascular events. Our goal was to assess the association of serum uric acid levels and the outcomes of patients who have undergone percutaneous coronary intervention (PCI). We performed a retrospective cohort study of patients who underwent PCI between 1/1/2000 and 12/31/2007. Data were retrieved from the Cardiac Lab Interventional Clinical Database as well as the medical records. Outcomes of mortality as well as major adverse cardiac events (MACE) that include death, myocardial infarction (MI), and target vessel revascularization were obtained. There were 10,632 unique patients who had a PCI at the Mayo Clinic in Rochester and allowed use of their records for research. During this time, 1,916 had a uric acid measure within 2 years prior to the day of PCI. Of the 1,916 patients in our cohort, 1,353 had normal uric acid levels and 563 had elevated uric acid. After multivariable analysis, there was a strong trend in association with follow-up mortality in patients with elevated uric acid (HR = 1.25, 95% CI 0.98-1.59, P = 0.07). The association with mortality or MI (HR = 1.15, 95% CI 0.93-1.43, P = 0.20) a...Continue Reading

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Feb 9, 1889·British Medical Journal·A Haig

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Citations

Jul 13, 2014·Cell Biochemistry and Biophysics·Liru YanChaoying Zhang
May 16, 2014·Diabetes/metabolism Research and Reviews·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Jul 4, 2012·Metabolism: Clinical and Experimental·Gjin NdrepepaAdnan Kastrati
Nov 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Akifumi KushiyamaTomoichiro Asano

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