The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes

Andrology
S RamachandranGeoffrey Hackett

Abstract

Serum sex hormone-binding globulin levels have been associated with mortality in adult men with type 2 diabetes (T2DM). To confirm the association of serum sex hormone-binding globulin with mortality and then determine whether this association is mediated by age and total testosterone concentration. We studied 364 men (median age: 66 years) with T2DM over a median follow-up of 4.3 years using the Cox regression to study associations between sex hormone-binding globulin, age, total testosterone, and mortality. Mortality was significantly and independently associated with sex hormone-binding globulin, age, and total testosterone. In pairwise combinations of age and sex hormone-binding globulin dichotomized by median values, the association of sex hormone-binding globulin with mortality was age-dependent. Relative to the combination of age >66 years/SHBG >35 nmol/L (mortality 22.5%), the other combinations were associated with significantly less mortality (mortality in men ≤66 years/SHBG ≤ 35 nmol/L was 3.23%). In men >66 years, SHBG ≤ 35 nmol/L was associated with decreased mortality (HR: 0.41, p = 0.037) compared with SHBG > 35 nmol/L. In men ≤66 years, there was no significant difference between those with sex hormone-binding g...Continue Reading

References

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Citations

Apr 25, 2020·Journal of Clinical Medicine·Artur Borowski, Lucyna Siemińska
Jul 11, 2020·International Journal of Clinical Practice·Mark LivingstonSudarshan Ramachandran
Oct 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Bu B YeapKevin Murray
Feb 22, 2021·Ageing Research Reviews·Nikolai JaschkeTilman D Rachner

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