The association of short-term memory and cognitive impairment with ghrelin, leptin, and cortisol levels in non-diabetic and diabetic elderly individuals

Acta Diabetologica
Yu Ming SangYi Jun Zhu

Abstract

This study assessed short-term memory and biochemical indicators with the levels of ghrelin, leptin, and cortisol between cognitive impairment and normal older adults with or without diabetes. We enrolled 286 older adults (aged 65-85 years) with or without diabetes from the local community. Short-term memory was assessed using pictures of common objects; cognitive functioning was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The physiological indexes assessed were plasma levels of fasting ghrelin and leptin, ghrelin level at 2_h after breakfast, 24-h urinary cortisol value, body mass index, and plasma cortisol levels at 8:00 a.m., 4:00 p.m., and 12:00 p.m. In both non-diabetic and diabetic subjects, short-term memory was significantly lower in the impaired cognition group (5.99 ± 2.90 in non-diabetic subjects and 4.71 ± 2.14 in diabetic subjects) than in the normal cognition group (8.14 ± 2.23 in non-diabetic subjects and 7.82 ± 3.37 in diabetic subjects). Baseline ghrelin level was significantly lower in the impaired cognition group (9.07 ± 1.13 ng/mL in non-diabetic subjects and 7.76 ± 1.34 ng/mL in diabetic subjects) than in the normal cognition group (10.94 ± 1.53 ng/m...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1989·The American Journal of Psychiatry·R G KatholW H Meller
Aug 18, 1988·The New England Journal of Medicine·P W GoldG P Chrousos
Dec 9, 1998·Journal of Psychiatric Research·I A AntonijevicA Steiger
Apr 16, 1999·Psychosomatic Medicine·J C PruessnerC Kirschbaum
Nov 1, 2000·Nature·M TschöpM L Heiman
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Jun 25, 2002·Annals of the New York Academy of Sciences·Eric Jéquier
Oct 30, 2004·Psychoneuroendocrinology·Sonia J LupienMai Thanh Tu
Dec 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Darius C FewlassNikolaos Tezapsidis
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Nov 11, 2005·Neurobiology of Aging·Arun S KarlamanglaTeresa E Seeman
Dec 6, 2005·Journal of Affective Disorders·Guey-Mei JowChun-Lan Chen
Dec 20, 2005·Lancet Neurology·Geert Jan BiesselsPhilip Scheltens
Jan 13, 2006·Psychiatry and Clinical Neurosciences·Omer GeciciBilal Ustundag
Feb 24, 2006·Nature Neuroscience·Sabrina DianoTamas L Horvath
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M D KlokM L Drent
Nov 21, 2007·Current Opinion in Pharmacology·Ewan C McNay
May 10, 2008·Journal of Neurochemistry·Armando P SignoreJun Chen
Apr 15, 2009·Vision Research·Paolo Martini, Vera Maljkovic
Apr 24, 2009·Journal of Alzheimer's Disease : JAD·Nikolaos TezapsidisSraboni Sarkar
Jun 3, 2009·Archives of General Psychiatry·Sophie A VreeburgBrenda W J H Penninx
Sep 1, 2009·The Psychiatric Clinics of North America·Elizabeth I MartinCharles B Nemeroff
Nov 10, 2009·Frontiers in Neuroendocrinology·T R CastañedaM H Tschöp
Mar 13, 2010·Clinical Chemistry·Jenni Harvey
Jun 19, 2010·Journal of Geriatric Psychiatry and Neurology·Joana Bisol BalardinElke Bromberg
Oct 30, 2010·Psychiatry and Clinical Neurosciences·Mary Beth SpitznagelJohn Gunstad
Feb 26, 2011·Molecular and Cellular Endocrinology·Axel SteigerMichael Kluge
May 15, 2012·Psychosomatic Medicine·Alanna A MorrisViola Vaccarino
Jun 13, 2012·The Journal of Clinical Psychiatry·Yuri MilaneschiUNKNOWN Health, Aging, and Body Composition Study
Mar 20, 2013·Neuroscience·I MartinsC M F Pereira
Mar 22, 2013·Therapeutic Advances in Endocrinology and Metabolism·Jacqueline A Bayliss, Zane B Andrews
Mar 30, 2013·Peptides·Fatemeh GoshadrouSamad Sajjadi
Apr 25, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vivian P LaraKarina B Gomes
Sep 14, 2013·Journal of Diabetes·Guang Ning, Zachary Bloomgarden
Mar 19, 2014·Psychoneuroendocrinology·Yuri MilaneschiLuigi Ferrucci
Sep 1, 2014·Neurobiology of Disease·I I Stoyanova
Dec 3, 2014·Psychoneuroendocrinology·Dirk Alexander Wittekind, Michael Kluge
Jun 15, 2015·Neuropeptides·Siamak Beheshti, Shahrzad Shahrokhi

❮ Previous
Next ❯

Citations

Oct 9, 2019·Molecular Psychiatry·Stefan R BornsteinRichard Straube
Sep 8, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Mu-Hong ChenYa-Mei Bai
Mar 19, 2019·Frontiers in Aging Neuroscience·Sami Ouanes, Julius Popp
Jun 23, 2020·International Journal of Endocrinology·Yonas AkaluBirhanu Ayelign

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.