The association of single umbilical artery with cytogenetically abnormal pregnancies

American Journal of Obstetrics and Gynecology
D N SallerS Schwartz


The clinical significance of the absence of one of the two umbilical arteries (single umbilical artery) lies in its association with congenital malformations. Whether this association includes cytogenetic abnormalities is less clear. A retrospective review of all detected chromosomally abnormal pregnancies at the University of Maryland was carried out. Of 109 cytogenetically abnormal pregnancies, the number of umbilical cord vessels could be documented in 53 cases. Six (11.3%) had a single umbilical artery. A single umbilical artery was noted in two of nine fetuses (22.2%) with trisomy 18 and in two of six fetuses (33.3%) with trisomy 13. Two other unusual chromosomal constitutions were noted in cases of a single umbilical artery. None of the 11 fetuses with sex chromosome abnormalities (including eight with monosomy X) had a single umbilical artery. Of 18 fetuses with trisomy 21, none had a single umbilical artery. This study suggests that a single umbilical artery is preferentially associated with certain karyotypic abnormalities and that trisomy 21 does not appear to be associated with a single umbilical artery.


May 1, 1988·Prenatal Diagnosis·U J Herrmann, D Sidiropoulos
May 1, 1988·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·D A NybergJ Fitzsimmons
Feb 1, 1985·American Journal of Obstetrics and Gynecology·J Byrne, W A Blanc
Oct 1, 1980·Journal of Clinical Ultrasound : JCU·M N JassaniI R Merkatz
Jul 1, 1964·The Journal of Pediatrics·A J LEWIS
Dec 1, 1960·Archives of Disease in Childhood·G L Bourne, K Benirschke

❮ Previous
Next ❯


Dec 23, 1999·American Journal of Medical Genetics·A DruganM I Evans
Nov 1, 1992·Prenatal Diagnosis·T Y Khong, K George
Oct 22, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mohamed Ibrahim KhalilTahany A L Halouly
Aug 1, 1997·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T SenerB Durak
Nov 13, 2001·Obstetrics and Gynecology·L M HillP Chenevey
Nov 9, 2002·Obstetrics and Gynecology·Dana R GossettChristian A Chisholm
Aug 1, 1997·Obstetrics and Gynecology·B UlmG Bernaschek
Jun 26, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A Weissman, A Drugan
May 19, 2009·Obstetrical & Gynecological Survey·Brooke T DaveyColin K L Phoon
Jan 1, 1991·Journal of Perinatal Medicine·W H Sepúlveda
Mar 7, 2014·Prenatal Diagnosis·Eran AshwalYariv Yogev
Jan 31, 2002·Clinics in Perinatology·J N Robinson, A Z Abuhamad
Mar 13, 2015·Prenatal Diagnosis·Shalini S NayakKatta M Girisha
Sep 1, 1995·American Journal of Obstetrics and Gynecology·A Z AbuhamadA T Evans
Jun 13, 1994·Ugeskrift for laeger·A Tabor, B S Ottesen
Apr 25, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A GeipelU Gembruch
Apr 15, 1993·American Journal of Medical Genetics·A K Leung, W L Robson
Jul 3, 1995·American Journal of Medical Genetics·J Kasznica, N M Maldonado
Apr 1, 1996·Pediatric Annals·J S Abramowicz, R Jaffe
May 1, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yajuan XuYingying Zhang
Dec 16, 1998·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·P M PavlopoulosP Davaris
Feb 2, 2015·Indian Pediatrics·Shalini S NayakKatta M Girisha

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Obstetrics and Gynecology
T B JonesS F Bottoms
Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
D A NybergR Kapur
© 2021 Meta ULC. All rights reserved