The association of the lipidomic profile with features of polycystic ovary syndrome

Journal of Molecular Endocrinology
L J MoranP J Meikle

Abstract

Polycystic ovary syndrome (PCOS) affects up to 18% of reproductive-aged women with reproductive and metabolic complications. While lipidomics can identify associations between lipid species and metabolic diseases, no research has examined the association of lipid species with the pathophysiological features of PCOS. The aim of this study was to examine the lipidomic profile in women with and without PCOS. This study was a cross-sectional study in 156 age-matched pre-menopausal women (18-45 years, BMI >20 kg/m2; n = 92 with PCOS, n = 64 without PCOS). Outcomes included the association between the plasma lipidomic profile (325 lipid species (24 classes) using liquid chromatography mass spectrometry) and PCOS, adiposity, homeostasis assessment of insulin resistance (HOMA), sex hormone-binding globulin (SHBG) and free androgen index (FAI). There were no associations of the lipidomic profile with PCOS or testosterone. HOMA was positively associated with 2 classes (dihydroceramide and triacylglycerol), SHBG was inversely associated with 2 classes (diacylglycerol and triacylglycerol), FAI was positively associated with 8 classes (ceramide, phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, lysophosphatidylethanola...Continue Reading

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Citations

Aug 9, 2018·Diabetes/metabolism Research and Reviews·Małgorzata Jacewicz-Święcka, Irina Kowalska
Jul 17, 2018·Endocrine Reviews·David J HandelsmanStephane Bermon
Dec 4, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yihong JiangShengxian Li
Sep 30, 2020·Pediatric Obesity·Cristina Garcia-BeltranLourdes Ibáñez
Nov 11, 2019·Molecular Reproduction and Development·Kate DuloherySabine Kölle
Jul 17, 2019·Taiwanese Journal of Obstetrics & Gynecology·Qi LiuZhong-Cheng Mo
May 5, 2021·Seminars in Reproductive Medicine·Simon AlesiAya Mousa
Jul 16, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Haixia SongYuhua Shi

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