The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study.

Human Genetics
Nora FranceschiniShelley A Cole

Abstract

Chronic kidney disease (CKD) is an important public health problem in American Indian populations. Recent research has identified associations of polymorphisms in the myosin heavy chain type II isoform A (MYH9) gene with hypertensive CKD in African-Americans. Whether these associations are also present among American Indian individuals is unknown. To evaluate the role of genetic polymorphisms in the MYH9 gene on kidney disease in American Indians, we genotyped 25 SNPs in the MYH9 gene region in 1,119 comparatively unrelated individuals. Four SNPs failed, and one SNP was monomorphic We inferred haplotypes using seven SNPs within the region of the previously described E haplotype using Phase v2.1. We studied the association between 20 MYH9 SNPs with kidney function (estimated glomerular filtration rate, eGFR) and CKD (eGFR\60 ml/min/1.73 m(2) or renal replacement therapy or kidney transplant) using age-, sex- and center-adjusted models and measured genotyped within the variance component models. MYH9 SNPs were not significantly associated with kidney traits in additive or recessive genetic adjusted models. MYH9 haplotypes were also not significantly associated with kidney outcomes. In conclusion, common variants in MYH9 polymorph...Continue Reading

References

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Citations

Nov 27, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rasheed GbadegesinMichelle Winn
Mar 25, 2011·Human Molecular Genetics·Conall M O'SeaghdhaW H Linda Kao
May 25, 2010·Seminars in Dialysis·Barry I Freedman, Mariana Murea
Apr 20, 2012·Kidney International·Nora FranceschiniJason G Umans
Aug 24, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anna Köttgen
Dec 7, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Nora FranceschiniShelley A Cole
Feb 27, 2013·Nature Reviews. Nephrology·Giulio GenoveseMartin R Pollak
May 4, 2011·Nature Reviews. Nephrology·Saharon RossetKarl Skorecki
Sep 20, 2019·International Journal of Nephrology·Cyril CyrusAmein K Al Ali

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