The association of the QT interval with atrial fibrillation and stroke: the Multi-Ethnic Study of Atherosclerosis

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Wesley T O'NealElsayed Z Soliman

Abstract

Prolongation of the QT interval is associated with an increased risk of atrial fibrillation (AF) and stroke. The purpose of this analysis was to determine if AF explains the association between prolonged QT and stroke. A total of 6305 participants (mean age 62 ± 10 years; 54% women; 38% whites; 27% blacks; 23% Hispanics; 12% Chinese-Americans) from the Multi-Ethnic Study of Atherosclerosis (MESA) were included in this analysis. A linear scale was used to compute heart rate-adjusted QT (QT(a)). Prolonged QT(a) was defined as ≥ 460 ms in women and ≥ 450 ms in men. Incident AF cases were identified using hospital discharge records and Medicare claims data. Vascular neurologists adjudicated stroke events by medical record review. Cox regression was used to examine the association between prolonged QT(a) and stroke with and without AF. A total of 216 (3.4%) of study participants had prolonged QT(a). Over a median follow-up of 8.5 years, 280 (4.4%) participants developed AF and 128 (2.0%) participants developed stroke. In a multivariable Cox regression analysis adjusted for socio-demographics, cardiovascular risk factors, and potential confounders, prolonged QT(a) was associated with an increased risk of AF (HR = 1.7, 95% CI 1.1, 2.6...Continue Reading

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Citations

Oct 31, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tobias ZeusAmin Polzin
Aug 16, 2016·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Hanumantha R JoguElsayed Z Soliman
Jul 1, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Nikhil PatelElsayed Z Soliman
Nov 10, 2018·The Journal of Physiology·Giedrius KanaporisLothar A Blatter
Dec 19, 2015·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Jurij Matija KališnikBorut Geršak
Nov 5, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Insa E EmrichStefanie M Bode-Böger
Sep 21, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Katherine C WuWendy S Post
Jan 31, 2018·Pacing and Clinical Electrophysiology : PACE·Nixiao ZhangTong Liu
Feb 26, 2020·PloS One·Claudia K SuemotoMelinda C Power

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