The Association of Unfavorable Traffic Events and Cannabis Usage: A Meta-Analysis

Frontiers in Pharmacology
Sorin HostiucEduard Drima

Abstract

Background: In the last years were published many epidemiological articles aiming to link driving under the influence of cannabis (DUIC) with the risk of various unfavorable traffic events (UTEs), with sometimes contradictory results. Aim: The primary objective of this study was to analyze whether there is a significant association between DUIC and UTEs. Materials and Methods: We used two meta-analytical methods to assess the statistical significance of the effect size: random-effects model and inverse variance heterogeneity model. Results: Twenty-four studies were included in the meta-analysis. We obtained significant increases in the effect size for DUIC tested through blood analysis, with an odds ratio (OR) of 1.97 and a confidence interval (CI) between 1.35 and 2.87; [corrected] death as an outcome, with an OR of 1.56 and a CI between 1.16 and 2.09; and case-control as the type of study, with an OR of 1.99 and a CI between 1.05 and 3.80. Publication bias was very high. Conclusion: Our analysis suggests that the overall effect size for DUIC on UTEs is not statistically significant, but there are significant differences obtained through subgroup analysis. This result might be caused by either methodological flaws (which are o...Continue Reading

References

Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·C H Ashton
Apr 10, 2003·Annals of Epidemiology·Susan Goodwin GerberichCharles P Quesenberry
Jul 10, 2003·Forensic Science International : Synergy·Olaf H DrummerPhilip Swann
Dec 25, 2003·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·M L ChipmanR E Mann
Jan 17, 2004·Drug and Alcohol Dependence·J G RamaekersO H Drummer
Apr 20, 2004·Accident; Analysis and Prevention·K L L MovigA C G Egberts
Feb 5, 2005·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·C ZwerlingM P Jones
Apr 26, 2005·Addiction·Stephanie BlowsRobyn Norton
Jun 7, 2005·Accident; Analysis and Prevention·Ahmad KhorashadiFred Mannering
Dec 3, 2005·BMJ : British Medical Journal·Bernard LaumonUNKNOWN SAM Group
Dec 7, 2007·Journal of Safety Research·Robert E MannMark Asbridge
Dec 20, 2007·Epidemiology·Suhail A R Doi, Lukman Thalib
Apr 28, 2009·Accident; Analysis and Prevention·Patarawan WoratanaratTongtavuch Anukarahanonta
Feb 12, 2011·BMJ : British Medical Journal·Richard D RileyJonathan J Deeks
Mar 8, 2011·Accident; Analysis and Prevention·Hallvard GjerdeJørg Mørland
May 7, 2011·Accident; Analysis and Prevention·Raquel De BoniFlavio Pechansky
Jun 7, 2011·Epidemiology·José PulidoUNKNOWN Itínere Project Group
Jun 21, 2011·Journal of Studies on Alcohol and Drugs·Eduardo Romano, Robert B Voas
Oct 7, 2011·Epidemiologic Reviews·Mu-Chen LiGuohua Li
Sep 7, 2012·PloS One·Kim Paula Colette KuypersAlain Gaston Verstraete
Nov 8, 2012·Forensic Science International : Synergy·Helen PoulsenCarolina Troncoso
Dec 12, 2012·Clinical Chemistry·Rebecca L Hartman, Marilyn A Huestis
Jul 23, 2013·Accident; Analysis and Prevention·Tove HelsInger Marie Bernhoft
Oct 1, 2013·Accident; Analysis and Prevention·Guohua LiQixuan Chen
Nov 20, 2013·Traffic Injury Prevention·Matthew E RossheimDennis L Thombs
Jan 15, 2014·Journal of Studies on Alcohol and Drugs·Edurado RomanoJohn H Lacey
May 25, 2015·Contemporary Clinical Trials·Suhail A R DoiGail M Williams
Apr 25, 2016·Accident; Analysis and Prevention·Rebecca L HartmanMarilyn A Huestis

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Citations

Dec 9, 2020·International Journal of Environmental Research and Public Health·Sonia Ortiz-PeregrinaRosario G Anera
Jun 15, 2021·Frontiers in Psychiatry·Ulrich W PreussEva Hoch

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