The association of vascular proliferation with HPV status and epithelial PCNA positivity in cervical intraepithelial lesions

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Y SoiniV P Lehto

Abstract

In this study we investigated the number of blood vessels and vascular proliferation in subepithelial areas of 80 cervical condylomas and cervical intraepithelial neoplasias (CIN). The number of blood vessels was determined by counting factor VIIIRAg-positive vascular channels in areas beneath the epithelial lesions. Vascular proliferation was evaluated by determining the number of proliferating cell nuclear antigen (PCNA)-positive endothelial cells in the subepithelial connective tissues. The results were compared with the expression of human papillomavirus (HPV) DNA subgroups (6/11 (low-risk) and 16/18/31/33/35 (high-risk) of the lesions, as determined by dot-blot and in situ hybridization, and with epithelial cell proliferation as determined by immunohistochemistry for PCNA. Also p53 immunohistochemistry of the lesions was performed. Even though CIN II-III lesions on average contained more factor VIIIRAg-positive blood vessels compared to condylomas and CIN I lesions, no significant association was found between their number and the degree of dysplasia. However, moderate or strong PCNA staining in vascular endothelial cells was seen significantly more often in CIN II-III lesions than in condylomas and CIN I lesions (p = 0.00...Continue Reading

References

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y SoiniK Vähäkangas
Feb 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S M Syrjänen
Sep 1, 1990·Journal of Clinical Microbiology·M RankiA Kallio
Nov 1, 1989·Journal of Virology·E M de Villiers
Oct 1, 1994·Gynecologic Oncology·P KarakitsosK Kyrkou
Feb 1, 1993·The American Journal of Surgical Pathology·K R MittalS Goswami

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Citations

Jun 20, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J MulleratC W Perrett

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