The associations of body composition and fat distribution with bone mineral density in elderly Italian men and women

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
S GonnelliR Nuti

Abstract

This study aimed to investigate the associations of body composition and fat distribution with bone mineral density (BMD) in elderly Italian subjects. In 866 women (age 64.2±6.5yr) and 168 men (age 65.1±6.1yr), we measured BMD at lumbar spine, at femur, at the total body, and at the right hand. In all subjects, we also measured sex hormones, 25-hydroxyvitamin D, bone markers, and calcium intake. In both men and women, all body composition parameters had significant positive correlations with BMD at all sites after adjusting for age only; after adjusting also for body weight only lean mass (LM) remained positively associated with BMD at all sites except BMD at lumbar spine. In males, LM was associated with BMD at all sites, whereas android fat was associated with BMD at lumbar spine, at femur, and at whole body. In females, fat mass (FM) was positively and age inversely associated with BMD at all sites, whereas gynoid fat and alkaline phosphatase were inversely associated with BMD at lumbar spine and at femur. In conclusion, the role of LM seems more important in males, whereas in women the role of FM prevails with negative associations between gynoid fat and BMD.

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Citations

Aug 21, 2014·Calcified Tissue International·S GonnelliR Nuti
May 13, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Jun ZhangQifeng Ying
Jul 10, 2016·Internal and Emergency Medicine·Carla CaffarelliPaola Rottoli
Nov 2, 2017·European Journal of Nutrition·Yannis ManiosKevin D Cashman
Dec 30, 2015·Journal of Bone Metabolism·Dae-Young LeeSeong-Hwan Moon
Oct 26, 2018·American Journal of Physical Anthropology·Alizé Lacoste JeansonJaroslav Brůžek
Mar 27, 2018·American Journal of Human Biology : the Official Journal of the Human Biology Council·Alizé Lacoste JeansonJaroslav Brůžek
Mar 26, 2021·Journal of Orthopaedic Surgery and Research·Wei-Hsiu HsuRobert Wen-Wei Hsu
Oct 11, 2021·BMC Musculoskeletal Disorders·Geise Ferreira da CruzValdete Regina Guandalini

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