The Associations of Diuretics and Laxatives Use with Cardiovascular Mortality. An Individual Patient-Data Meta-analysis of Two Large Cohort Studies

Cardiovascular Drugs and Therapy
Liesa Katharina HoppeBen Schöttker

Abstract

To investigate the associations of diuretics overall, non-potassium-sparing diuretics in specific, and laxative use with cardiovascular mortality (CVM) in subjects with antihypertensive treatment. Analyses included 4253 participants, aged 50 to 75 years, from the German ESTHER cohort and 105,359 participants, aged 50 to 69 years, from the UK Biobank. Cox proportional hazard regression models were applied in both studies, and then results were pooled using random-effects model meta-analyses. During 14 and 7 years of follow-up, 476 and 1616 CVM cases were observed in the ESTHER study and the UK Biobank, respectively. Compared to non-users, a 1.6-fold (hazard ratio [95% confidence interval] 1.57 [1.29; 1.90]), a 1.4-fold (1.39 [1.26; 1.53]), and no statistically significantly increased (1.13 [0.94; 1.36]) CVM were observed in users of diuretics overall, non-potassium-sparing diuretics in specific, and laxatives, respectively. Concurrent use of non-potassium-sparing diuretics and laxatives was associated with a 2-fold increased CVM (2.05 [1.55; 2.71]) when compared to users of neither diuretics nor laxatives. However, a test for interaction slightly missed statistical significance (p = 0.075). These consistent results from two larg...Continue Reading

References

Mar 6, 1990·The American Journal of Cardiology·M Schulman, R G Narins
Nov 5, 1984·The American Journal of Medicine·J W Hollifield
Aug 6, 1998·The New England Journal of Medicine·D C Brater
Sep 6, 2001·Diseases of the Colon and Rectum·J H Xing, E E Soffer
Oct 26, 2002·The Annals of Pharmacotherapy·Ingeborg K BjörkmanUNKNOWN Pharmaceutical Care of the Elderly in Europe Research (PEER) Group
May 22, 2003·JAMA : the Journal of the American Medical Association·Bruce M PsatyNoel S Weiss
Oct 31, 2003·American Journal of Epidemiology·Wayne A Ray
Sep 22, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Daniel C MaloneRichard B Lipton
Jun 19, 2007·Lancet·Lyle J Palmer
Dec 26, 2008·JAMA : the Journal of the American Medical Association·Dima M QatoStacy Tessler Lindau
May 6, 2009·Annals of Internal Medicine·Megan GreenleeBruce C Kone
Jan 31, 2012·Journal of the American Geriatrics Society·Paul E DrawzMahboob Rahman
Apr 3, 2012·Lancet·Rory Collins
Oct 30, 2012·Lancet·Roy M JohnWilliam G Stevenson
Nov 28, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Xueya CaiMalaz Boustani
Sep 10, 2013·International Journal of Cardiology·Bouwe P KrijtheBruno H Stricker
May 28, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B E LacyF Mearin
May 27, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ying-Ho LaiWen-Harn Pan
Nov 5, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·N AmlerO Schöffski
Aug 5, 2016·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Barry L WerthLisa G Pont
Aug 19, 2016·Kidney Diseases·Miriam ZacchiaGiovambattista Capasso
Mar 20, 2018·European Heart Journal·Csaba P KovesdyUNKNOWN CKD Prognosis Consortium
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Nov 23, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Si SiDanny Liew

❮ Previous
Next ❯

Software Mentioned

ESTHER
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
P J Phillippi
Naika. Internal medicine
E Kate, Y Ozawa
Nihon rinsho. Japanese journal of clinical medicine
Shunichi Ihara, Masatoshi Kawana
© 2021 Meta ULC. All rights reserved