The associations of "fatness," "fitness," and physical activity with all-cause mortality in older adults: A systematic review

Obesity
Dharani YerrakalvaJonathan Mant

Abstract

This review explored whether cardiorespiratory fitness or physical activity act as either confounders or effect modifiers of the relationship between adiposity markers and all-cause mortality in older adults. Systematic searches were carried out to identify observational studies that examined the association of adiposity markers (BMI, waist circumference, and waist-hip ratio) with all-cause mortality in adults aged ≥ 60 which took into account cardiorespiratory fitness or physical activity. Data from each included study was analyzed to produce a graphical representation of this relationship. Fourteen of the fifteen identified studies found that increasing BMI had a non-positive association with all-cause mortality, with persistence of the obesity paradox despite adjustment for physical activity or cardiorespiratory fitness. Physical activity measurement methods were all subjective and often unvalidated. The two studies stratifying for cardiorespiratory fitness did not find that fitness had a significant impact on the relationship between excess adiposity and mortality but found that overweight and fit people had better survival than normal-weight unfit people, The predominant use of poor physical activity measurement suggests t...Continue Reading

References

Oct 1, 1985·Pflügers Archiv : European journal of physiology·L Budohoski
Jun 1, 1994·Journal of the American Dietetic Association·R P Abernathy, D R Black
Nov 22, 1997·Journal of Clinical Epidemiology·M WeiS N Blair
Jan 1, 1998·The New England Journal of Medicine·J StevensJ L Wood
Mar 13, 1999·The American Journal of Clinical Nutrition·C D LeeA S Jackson
Nov 5, 1999·JAMA : the Journal of the American Medical Association·M WeiS N Blair
Apr 27, 2001·Medicine and Science in Sports and Exercise·P T Williams
Jun 28, 2001·Medicine and Science in Sports and Exercise·S N BlairJ S Holder
Apr 3, 2002·Annals of Internal Medicine·Seamus P WheltonJiang He
May 15, 2002·Obesity Research·Petra H LahmannGöran Berglund
Jul 23, 2002·Journal of the American Geriatrics Society·Soham Al SnihJames S Goodwin
Mar 30, 2004·Journal of Applied Physiology·Liza StathokostasDonald H Paterson
May 29, 2004·American Journal of Preventive Medicine·Yuko Oguma, Tomoko Shinoda-Tagawa
Feb 8, 2005·The American Journal of Cardiology·Luis GrubergUNKNOWN Arterial Revascularization Therapies Study Investigators
Jun 1, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M ZamboniO Bosello
Feb 14, 2006·The American Journal of Clinical Nutrition·Kamyar Kalantar-ZadehJoel D Kopple
Apr 28, 2006·American Journal of Epidemiology·María M CorradaAnnlia Paganini-Hill
Jul 26, 2006·Archives of Internal Medicine·C Mary SchoolingGabriel M Leung
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·I Janssen, A E Mark
Jan 24, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Darren Schmidt, Abdulla Salahudeen
Jun 20, 2007·European Heart Journal·Heinz J BuettnerFranz-Josef Neumann
Aug 25, 2007·The Journal of Clinical Investigation·Ja-Young KimPhilipp E Scherer
Dec 7, 2007·JAMA : the Journal of the American Medical Association·Xuemei SuiSteven N Blair
Mar 29, 2008·Journal of Applied Physiology·Rebekah M SteeleUlf Ekelund
Jul 1, 2008·American Heart Journal·Antigone OreopoulosFinlay A McAlister
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Feb 7, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Paul McAuleyVictor F Froelicher
Apr 11, 2009·Obesity·Pilar Guallar-CastillónFernando Rodríguez-Artalejo
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Rachel P Wildman
Jul 25, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tung Wai AuyeungJean Woo
Jul 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nathan A JohnsonJacob George
Sep 8, 2009·European Heart Journal·Wolfram DoehnerStefan D Anker
Sep 12, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Fogelholm
Feb 2, 2010·Mayo Clinic Proceedings·Paul A McAuleyJonathan N Myers
Mar 31, 2010·Medicine and Science in Sports and Exercise·Stephen W FarrellCarolyn E Barlow
Oct 15, 2010·Journal of Psychopharmacology·Duck-chul LeeSteven N Blair
Jan 26, 2011·Nature Reviews. Cardiology·Beatriz Cepeda-ValeryAbel Romero-Corral
Feb 16, 2011·Journal of Epidemiology and Community Health·Jan-Magnus KvammeBjarne K Jacobsen
Feb 19, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A MenkeE Guallar

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Citations

Jul 14, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S AntonopoulosD Tousoulis
Nov 5, 2016·Eating and Weight Disorders : EWD·Alessandro Lechi
May 27, 2017·Cardiovascular Research·Alexios S Antonopoulos, Dimitris Tousoulis
Dec 1, 2018·The Journal of Nutrition, Health & Aging·J Fernandes de Souza BarbosaR Oliveira Guerra
Mar 14, 2020·Journal of Applied Research in Intellectual Disabilities : JARID·Alyt Oppewal, Thessa I M Hilgenkamp
Oct 3, 2018·Journal of Strength and Conditioning Research·Alex S RibeiroEdilson S Cyrino
Mar 1, 2017·Journal of Obesity & Metabolic Syndrome·Hye Jin Yoo
Apr 23, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ayesha A JavedParminder Raina
Jun 25, 2020·Brazilian Oral Research·Eduardo José Pereira OliveiraFabíola Bof DE Andrade
Dec 31, 2020·Nutrients·Pablo Jorge Marcos-PardoRaquel Vaquero-Cristóbal
Mar 7, 2021·International Journal of Environmental Research and Public Health·Francesco SartorHans-Peter Kubis
Jun 22, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David Navarrete-VillanuevaJosé Antonio Casajús

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