PMID: 6403455Jan 1, 1983Paper

The associations of HLA and other genetic markers with glomerulonephritis

Human Genetics
H U RashidD N Kerr

Abstract

One hundred and seventy-nine patients with various forms of glomerulonephritis confirmed histologically were tested for HLA A and B antigens: Thirty-four with membranous glomerulonephritis were also typed for DR antigens. One hundred and forty-one of these patients were further tested for blood group, red cell enzyme, and plasma protein systems. The minimal-change and the mesangio-capillary glomerulonephritis showed a significant association with B8 and Bw44 antigens respectively, whereas the membranous nephritis in addition to B8 was also found to be associated with DR3 antigen. Previously described associations with Henoch-Schönlein and Berger's nephritis were not proved. A large group with nonspecific proliferative glomerulonephritis did not show any association with HLA. Among the other single-gene characters studied, a significant association was found with Bf (Factor B or C3 proactivator) and adenosine deaminase, both markers thought to be involved in the immune response. The close association of the markers located on chromosome 6 and glomerulonephritis indicates that there may be an immunological component in the aetiology of the disease. The significance of the various associations found is discussed.

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Citations

Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J F Knight
Dec 1, 1985·Irish Journal of Medical Science·O BrowneE Campbell
Jun 5, 1986·The New England Journal of Medicine·T R WelchC D West
Mar 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanE R Heise
Oct 1, 1989·Kidney International·P A FrymoyerJ Gavalchin
Dec 1, 1986·Kidney International·H E FeuchtG J O'Neill
Oct 1, 1986·Kidney International·C E Alpers, R S Cotran
Mar 1, 1993·Kidney International·M L van VelthuysenG J Fleuren
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·John NearyPeter Conlon
Dec 17, 2008·Notes and Records of the Royal Society of London·Julyan H E Cartwright, Hisami Nakamura

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