PMID: 9650696Jul 3, 1998Paper

The asteroid bodies of sporotrichosis

The American Journal of Dermatopathology
G Rodríguez, L Sarmiento

Abstract

Some believe that asteroid bodies (AB) in sporotrichosis are nonspecific and are equivalent to the AB of sarcoidosis and other granulomatous diseases. We studied 25 skin biopsy specimens of sporotrichosis in which AB were demonstrated, ten of them with Sporothrix-positive culture. Immunohistochemistry was performed in paraffin-embedded biopsy specimens using an anti-Sporothrix antibody. The same procedures were done with seven biopsy specimens of lobomycosis, which contained AB within giant cells. These did not react with the anti-Sporothrix antibody, and by electron microscopy they displayed filamentous and myelin figures similar to the AB of sarcoidosis. In sporotrichosis, the AB are extracellular eosinophilic structures, 15-35 microm in diameter, and located within abscesses. One to three are found in a section. They consist of a central yeast, surrounded by eosinophilic spicules. The yeast stains with the anti-Sporothrix antibody, while the spicules do not. Therefore, AB in sporotrichosis are specific for disease. Visualization of the spicules alone can lead to the demonstration of the AB in adjacent sections, and thus is a useful clue in the diagnosis of sporotrichosis. Sporotrichotic AB must not be confused with the intra...Continue Reading

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Citations

Jan 1, 1996·Mycopathologia·G Rodriguez, G P Barrera
Mar 26, 2010·Cornea·Tomoyuki KashimaJunko Hirato
Sep 12, 2007·Pediatric Dermatology·Alexandro BonifazJavier Araiza
Apr 13, 2011·Clinical Microbiology Reviews·Jeannette Guarner, Mary E Brandt
Nov 17, 2009·Revista iberoamericana de micología·Alvaro OrellanaRoberto Arenas
Nov 10, 2004·International Journal of Dermatology·Eduardo S CivilaRaúl A Vignale
Apr 30, 2013·International Journal of Dermatology·Sofia Mata-EssayagEtna Velasquez
Feb 24, 2011·International Journal of Dermatology·V RameshMalini Capoor
Oct 5, 2010·Journal of Cutaneous Pathology·Leonardo Pereira QuintellaArmando De Oliveira Schubach
Feb 15, 2001·Experimental and Molecular Pathology·D S BrennerJ C Papadimitriou
Jan 11, 2011·The Veterinary Journal·Luisa H M MirandaTânia M P Schubach
Jan 24, 2015·Dermatology Research and Practice·Vikram K Mahajan
Oct 10, 2002·Clinical and Experimental Dermatology·R Morris-Jones
Mar 21, 2002·International Journal of Dermatology·T De AraujoF Kerdel
Jul 3, 2021·Biomédica : revista del Instituto Nacional de Salud·Paola MacíasGerzaín Rodríguez

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