The astroglial response to Wallerian degeneration after spinal cord injury in humans

Experimental Neurology
W R PuckettR P Bunge

Abstract

We describe the changes exhibited by astrocytes in areas of Wallerian degeneration after spinal cord injury in humans using glial fibrillary acidic protein immunohistochemistry correlated to standard histology at time points ranging from 8 days to 23 years after injury. Astrocytes were slow to react; a slight increase in immunoreactivity was observed at 4 months. Over time they began to lose immunoreactivity in both the somata and the processes as the debris from the degenerative process was cleared. By 1 year after injury the staining intensity had decreased to levels which were lower than in normal areas of the cord. This hypointense staining persisted for at least 23 years after injury. These findings are significantly different from those observed in animal studies and emphasize the need for additional pathological studies of human spinal cord injury.

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Citations

Apr 25, 2006·Journal of Neurotrauma·Theo Hagg, Martin Oudega
Jun 18, 2014·Journal of Neurotrauma·Amy L Bowes, Ping K Yip
May 16, 2012·The Journal of Physiology·Martin Oudega, Monica A Perez
Jul 16, 2011·Journal of Neuropathology and Experimental Neurology·Ingo SpitzbarthAndreas Beineke
Nov 11, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Li WangXiao-Ming Xu
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Feb 14, 2004·European Journal of Radiology·Clemens FitzekPeter Stoeter
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Apr 19, 2002·Brain : a Journal of Neurology·Blair CalancieJames G Broton
Dec 12, 2018·Neural Regeneration Research·Mallory E FilippAmgad S Hanna

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