PMID: 9553752Apr 29, 1998Paper

The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats

Endocrine Research
G MazzocchiG G Nussdorfer

Abstract

The role played by AT1 and AT2 receptors in the mediation of angiotensin-II (ANG-II) aldosterone secretagogue action has been investigated in vitro using different types of rat adrenal preparations. ANG-II enhanced aldosterone secretion of dispersed zona glomerulosa (ZG) cells in a concentration-dependent manner (EC50, 3 x 10(-10) M), and its effect was annulled by the AT1-receptor antagonist DuP753 and unaffected by the AT2-receptor antagonist PD123319. ANG-II was significantly more effective in stimulating aldosterone secretion when capsule-ZG and adrenal slices containing medullary chromaffin cells were used (EC50, 1 x 10(-11) M and 7 x 10(-12) M, respectively); moreover, both DuP753 and PD123319 caused partial reversals (intense and moderate, respectively) of the responses to ANG-II, and when added together annulled them. The beta-adrenoceptor antagonist l-alprenolol did not affect aldosterone response to ANG-II of dispersed ZG cells, but exerted a PD123319-like effect on the responses of capsule-ZG and adrenal slices. In light of these findings we conclude that, when the integrity of adrenal tissue is preserved, ANG-II stimulates aldosterone secretion by activating both AT1 and AT2 receptors, the major role being played by...Continue Reading

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Citations

Apr 8, 1999·Journal of the American College of Cardiology·H P Brunner-La RoccaM D Esler
Sep 17, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David Z I CherneyHeather N Reich
Jan 30, 2015·American Journal of Hypertension·Gisele S LinceviciusRuy R Campos
Jun 3, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carlos M Ferrario, Adam E Mullick
Oct 11, 2017·Nutrition Research and Practice·Eun-Gyung MunYoun-Soo Cha
Nov 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karine BibeauMichèle Brochu
Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Barbara PetersSigrid C Hoffmann
Sep 26, 2020·Frontiers in Endocrinology·Ming-Hui ZhengLing-Qing Yuan

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