The atherosclerosis burden score (ABS): a convenient ultrasound-based score of peripheral atherosclerosis for coronary artery disease prediction

Journal of Cardiovascular Translational Research
Patrick YerlyMichèle Depairon

Abstract

Ultrasonographic detection of subclinical atherosclerosis improves cardiovascular risk stratification, but uncertainty persists about the most discriminative method to apply. In this study, we found that the "atherosclerosis burden score (ABS)", a novel straightforward ultrasonographic score that sums the number of carotid and femoral arterial bifurcations with plaques, significantly outperformed common carotid intima-media thickness, carotid mean/maximal thickness, and carotid/femoral plaque scores for the detection of coronary artery disease (CAD) (receiver operating characteristic (ROC) curve area under the curve (AUC) = 0.79; P = 0.027 to <0.001 with the other five US endpoints) in 203 patients undergoing coronary angiography. ABS was also more correlated with CAD extension (R = 0.55; P < 0.001). Furthermore, in a second group of 1128 patients without cardiovascular disease, ABS was weakly correlated with the European Society of Cardiology chart risk categories (R(2) = 0.21), indicating that ABS provided information beyond usual cardiovascular risk factor-based risk stratification. Pending prospective studies on hard cardiovascular endpoints, ABS appears as a promising tool in primary prevention.

References

Aug 5, 1978·British Medical Journal·P J JenkinsP J Nestel
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Mar 29, 2001·AIDS·M DepaironUNKNOWN Swiss HIV Cohort Study
Jul 7, 2001·Stroke; a Journal of Cerebral Circulation·A I del SolM L Bots
Mar 7, 2002·The American Journal of Cardiology·J David Spence
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·J David SpenceTara Lohmann
Sep 6, 2003·Stroke; a Journal of Cerebral Circulation·M HollanderM M B Breteler
Sep 19, 2003·Journal of the American College of Cardiology·Sammy Y ChanAndrew Ignaszewski
Jun 17, 2004·Circulation·Eric de GrootJohn J P Kastelein
Apr 3, 2007·Journal of the American College of Cardiology·Iftikhar J Kullo, A Rauoof Malik
Oct 6, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·John E PostleyJulius M Gardin
Nov 28, 2009·Journal of the American College of Cardiology·Peter LibbyUNKNOWN Leducq Transatlantic Network on Atherothrombosis
May 14, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Sanne A E PetersMichiel L Bots
Jun 24, 2011·European Journal of Preventive Cardiology·Suzette E Elias-SmaleJacqueline C M Witteman
Apr 2, 2013·Heart, Lung & Circulation·Kenichi SakakuraRenu Virmani
Mar 14, 2014·Redox Biology·Maria WallertStefan Lorkowski
Mar 25, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C CaselliD Giannessi
Apr 9, 2014·Cardiology Research and Practice·Jaspinder Kaur
Aug 15, 2014·Journal of Cardiovascular Translational Research·Leticia Fernández-FrieraValentín Fuster

❮ Previous
Next ❯

Citations

Nov 17, 2015·International Journal of Environmental Research and Public Health·Huiping ZhangWenjie Sun
May 29, 2016·Angiology·Pierleone LucatelliEmanuela Medda
Feb 7, 2020·European Heart Journal Cardiovascular Imaging·Muriel Sprynger, Alexandra Girbea
Aug 12, 2020·Current Cardiology Reports·Nicholas GrubicAmer M Johri
Apr 2, 2021·VASA. Zeitschrift für Gefässkrankheiten·Angeliki KoulouriMichèle Depairon
Apr 27, 2021·Primary Care Diabetes·Angeladine Kenne MalahaVictor Aboyans
Jul 10, 2021·The International Journal of Cardiovascular Imaging·Kayla N ColledanchiseAmer M Johri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.