The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses?

Immunological Reviews
B Rolstad

Abstract

Athymic nude rats resemble nude mice in their lack of a normal thymus and functionally mature T cells. They have been useful in the study of mechanisms of tumor growth or graft rejection in immunocompromised hosts since they can accept major histocompatibility complex (MHC) mismatched organ allografts or xenografts for several months and because a number of tumor cell lines of human and rodent origin grow well in these rats. Injection of a few helper T (Th) cells from euthymic littermate rats partly restores the pool of mature T cells as well as full immunocompetence to reject organ allografts and has helped to reveal some of the cell interactions necessary for rejection to occur In contrast, immunologically naive athymic nude rats of certain strains, acutely reject allografts consisting of lymphocytes or bone marrow cells, which is due to the presence of alloreactive natural killer cells. These cells can recognize and kill MHC incompatible hematopoietic cells through the recognition of both mismatches within the classical (RT1.A) and nonclassical (RT1.C/E) MHC class I regions with a repertoire of inhibitory and activating killer lectin-like receptors (KLR) for MHC-I molecules, encoded by the Ly-49 portion of the rat natural ki...Continue Reading

Citations

Jan 14, 2009·Cancer Immunology, Immunotherapy : CII·Judith A M MarxAndrea Kindler-Röhrborn
Dec 7, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Claude Szpirer, Josiane Szpirer
Mar 24, 2004·Experimental Gerontology·Galina V ShurinMichael R Shurin
May 13, 2006·Journal of Neurotrauma·Jason R PotasPhil M E Waite
Mar 7, 2009·Tissue Engineering. Part a·Rohini GuptaMichael V Sefton
Jun 9, 2012·Neuro-oncology·Peter C HuszthyRolf Bjerkvig
Jan 13, 2006·Plastic and Reconstructive Surgery·Kevin A BrennerJay W Calvert
Aug 27, 2011·Circulation Research·Rasa TamosiunieneMark R Nicolls
Apr 2, 2014·Medical Engineering & Physics·Saranne J CookKent N Bachus
Aug 27, 2013·The Journal of Surgical Research·Sagar DeshpandeBenjamin Levi
Apr 20, 2010·Brain Research·Catherine Anne GorriePhil M E Waite
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Corinna DoegeBjoern Nashan
Sep 20, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Toshiyuki YanoKazuaki Shimamoto
May 6, 2015·Journal of Neuroscience Methods·Timothy KeatingMihir Baxi
Jul 21, 2012·Trends in Cardiovascular Medicine·Rasa Tamosiuniene, Mark R Nicolls
Mar 23, 2013·The American Journal of Pathology·Mark L OrmistonDavid W Courtman
Jun 25, 2016·Journal of Tissue Engineering and Regenerative Medicine·Ashley B AllenRobert E Guldberg
Jun 30, 2018·Journal of Tissue Engineering and Regenerative Medicine·Silvia BarbonClaudio Grandi
Aug 12, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Michiko SugawaraTsutomu Yoshimura
Jun 21, 2019·Viruses·Laura CorneilliePhilip Meuleman
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isabel BaraoJoao L Ascensao
May 28, 2019·Journal of Materials Science. Materials in Medicine·Ibrahim Fatih CengizJoaquim Miguel Oliveira
Dec 20, 2018·Journal of Biomedical Materials Research. Part a·Laura G BracagliaJohn P Fisher
Sep 20, 2017·Tissue Engineering. Part a·Athanasios BramosAlex K Wong
Feb 19, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Britney O Pennington, Dennis O Clegg
Jan 10, 2018·Nutrition and Cancer·Ann Marie O'NeillMichael W Greene
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter C HuszthyRolf Bjerkvig
Feb 20, 2021·Stem Cell Reports·Jun SongJie Xu
Mar 24, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Xiaoyu CaiHenning Madry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2022 Meta ULC. All rights reserved