PMID: 15377897Sep 21, 2004Paper

The ATP-sensitive potassium-channel inhibitor glibenclamide improves outcome in an ovine model of hemorrhagic shock

Shock
Dirk M MaybauerDaniel L Traber

Abstract

This study was designed as a prospective laboratory experiment to evaluate the effects of the ATP-sensitive potassium-channel inhibitor glibenclamide on hemodynamics and end-organ function in an ovine model of hemorrhagic shock. Twenty-four adult sheep were anesthetized and surgically prepared to measure hemodynamics of the systemic and pulmonary circulation. The anterior surface of the abdominal aorta was exposed at a location 6 cm superior to the iliac bifurcation. After a 60-min period of stabilization, this location was punctured with a 14-G needle. To induce a hemorrhagic hypotension (mean arterial pressure [MAP] less than 50 mmHg) via bleeding, the needle was left in place for 15 s to insure good blood flow. Thereafter, it was removed, and the abdomen closed. The animals were then randomized to receive either glibenclamide (4 mg/kg over 15 min) or an equal volume of the vehicle, started 1 h postinjury. Hemodynamic variables were measured every 30 min. Compared with the control group, MAP and systemic vascular resistance index (SVRI) were significantly higher in the intervention group throughout the entire 6-h study period. Ileal pH and urine output were higher in treated than in control animals (4 h, ileal pH 7.29 +/- 0.3...Continue Reading

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Citations

May 16, 2007·Intensive Care Medicine·Marc O MaybauerDaniel L Traber
Jun 12, 2010·The Journal of Trauma·Joel Avancini Rocha FilhoJosé O C Auler
Jan 7, 2014·British Journal of Anaesthesia·C VollmerO Picker
Apr 30, 2008·Current Opinion in Anaesthesiology·Matthias LangeMartin Westphal
Jan 10, 2006·Critical Care Clinics·Pierre AsfarMartin Matejovic
Jun 1, 2005·Lancet·Yoon K Loke
Oct 14, 2010·American Journal of Hypertension·Rui SongKe-Seng Zhao

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