The atrial natriuretic peptide receptor antagonist HS 142-1 improves cardiovascular filling and mean arterial pressure in a hyperdynamic ovine model of sepsis

Critical Care Medicine
F HinderD L Traber

Abstract

To test whether systemic vascular resistance and mean arterial pressure increase during the administration of the atrial natriuretic peptide antagonist, HS 142-1, in ovine experimental hyperdynamic sepsis. Prospective trial. Research laboratory at a large university medical center. Chronically instrumented Merino breed ewes (n = 14). Continuous infusion of Pseudomonas aeruginosa (2.5 x 10(6) colony-forming units/min) for the experimental period of 48 hrs. One group (HS 142-1) received a continuous infusion of HS 142-1 (3 mg/kg/hr) from 40 to 48 hrs; the remaining sheep ("control") were given the vehicle sodium chloride 0.9%. All sheep developed a hyperdynamic cardiovascular response by 40 hrs that was characterized by low values of systemic vascular resistance index (p < .05) and mean arterial pressure (p < .05), and an increased cardiac index (p < .05). HS 142-1 increased cardiac filling pressures (p < .05) without apparent effects on fluid balance, and was associated with a significantly (p < .05) higher mean arterial pressure than was found in the control group at 44 and 48 hrs. HS 142-1 did not change systemic vascular resistance index. At 44 and 48 hrs, cardiac index values were found to have significantly (p < .05) increa...Continue Reading

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Citations

Jan 3, 2001·The British Journal of Surgery·S J Parker, P E Watkins
Mar 9, 2000·Critical Care Medicine·D L Traber
Dec 16, 2004·Critical Care Medicine·Henning D StubbeFrank Hinder
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rochus Witthaut
Jul 24, 2010·British Journal of Pharmacology·Catherine M PanayiotouAdrian J Hobbs
Sep 1, 2005·Burns : Journal of the International Society for Burn Injuries·Hiroyuki SakuraiDaniel L Traber
Mar 11, 2021·Evolutionary Anthropology·Jessica F Brinkworth, Negin Valizadegan

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