The attenuation of dysfunctional emotional processing with stimulant medication: an fMRI study of adolescents with ADHD

Psychiatry Research
Jonathan PosnerBonnie J Nagel


Functional neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the neural correlates of cognitive control. However, for many youths with ADHD, emotional lability is an important clinical feature of the disorder. We aimed to identify the neural substrates associated with emotional lability that were distinct from impairments in cognitive control and to assess the effects that stimulants have on those substrates. We used functional magnetic resonance imaging (fMRI) to assess neural activity in adolescents with (N=15) and without (N=15) ADHD while they performed cognitive and emotional versions of the Stroop task that engage cognitive control and emotional processing, respectively. The participants with ADHD were scanned both on and off stimulant medication in a counterbalanced fashion. Controlling for differences in cognitive control, we found that during the emotional Stroop task, adolescents with ADHD as compared with controls demonstrated atypical activity in the medial prefrontal cortex (mPFC). Stimulants attenuated activity in the mPFC to levels comparable with controls.


Feb 1, 1992·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Edmund J S Sonuga-BarkeJ Smith
May 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·D ShafferD Regier
Jul 1, 1996·Psychological Bulletin·J M WilliamsC MacLeod
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R Damasio
Aug 26, 1998·The Journal of Comparative Neurology·N L Rempel-Clower, H Barbas
Feb 29, 2000·Journal of Clinical Child Psychology·J W Maedgen, C L Carlson
Apr 21, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·C P LucasP Friman
Jan 22, 2003·Nature Neuroscience·A K AndersonN Sobel
Feb 1, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rosa van MourikJoseph A Sergeant
Jan 20, 2006·Human Brain Mapping·Rachel MarshBradley S Peterson
Mar 9, 2007·Journal of Child and Adolescent Psychopharmacology·C J KratochvilR Swindle
Apr 5, 2007·Nature Protocols·George BushScott L Rauch
Aug 28, 2007·NeuroImage·Marcus E Raichle, Abraham Z Snyder
Nov 3, 2007·The American Journal of Psychiatry·B J CaseyGary Glover
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·P ShawJ L Rapoport
Mar 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Damien FairBradley L Schlaggar
Jan 9, 2009·Journal of the International Neuropsychological Society : JINS·Heather G BelangerLarry A Tupler
Mar 14, 2009·Brain Research·Catherine FassbenderJulie B Schweitzer
May 5, 2009·PLoS Computational Biology·Damien FairSteven E Petersen
Feb 6, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Esther SobanskiStephen V Faraone
Sep 22, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Alessandra M PassarottiMani N Pavuluri
Apr 1, 1988·Journal of Youth and Adolescence·A C PetersenA Boxer


Aug 20, 2014·Current Psychiatry Reports·Jonathan PosnerLeslie A Hulvershorn
Aug 2, 2012·Current Psychiatry Reports·Samuele Cortese, F Xavier Castellanos
Jul 23, 2013·Brain and Cognition·S López-MartínL Carretié
Apr 18, 2014·Expert Review of Neurotherapeutics·Katya RubiaHelen Brinson
Feb 26, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Leslie A HulvershornAmy Krain Roy
Mar 12, 2016·European Archives of Psychiatry and Clinical Neuroscience·Jessica YarmolovskyRonny Geva
Mar 1, 2015·European Child & Adolescent Psychiatry·Karen E SeymourDaniel P Dickstein
Dec 14, 2011·Biological Psychiatry·Dardo Tomasi, Nora D Volkow
Apr 12, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Philip Asherson, Bru Cormand
Apr 30, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Karen E SeymourDaniel P Dickstein
Jan 24, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Daniel P Dickstein
Dec 3, 2014·Human Movement Science·Thomas A DudaNancy McNevin
May 18, 2016·Clinical Psychology Review·Paulo A Graziano, Alexis Garcia
Aug 9, 2016·BMC Ear, Nose, and Throat Disorders·Dennis GolmBirgit Kröner-Herwig
May 18, 2017·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Ili MaAnouk Scheres
Apr 26, 2017·Frontiers in Human Neuroscience·Róisín McKennaKate A Woodcock
Feb 21, 2018·Developmental Neuropsychology·Khatereh Borhani, Vahid Nejati
Mar 24, 2018·Human Brain Mapping·Nora C VetterVeit Roessner
Aug 5, 2017·European Archives of Psychiatry and Clinical Neuroscience·Anna ShushakovaAnya Pedersen
Jan 20, 2018·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Amanda CremoneRebecca M C Spencer
Jul 27, 2018·Journal of Attention Disorders·Shereen ElmaghrabiF Xavier Castellanos
Dec 28, 2018·Brain and Behavior·Blair UniackeJoanna Steinglass
Feb 10, 2018·European Archives of Psychiatry and Clinical Neuroscience·Alexander SchneidtMichael Schönenberg
May 22, 2019·Expert Opinion on Pharmacotherapy·Giulio PerugiPietro De Rossi
Feb 28, 2020·Development and Psychopathology·Johan Lundin KlebergKarin C Brocki
Mar 31, 2016·Journal of Child and Adolescent Psychopharmacology·Lucas BattelAlexandre Rosa Franco
Jan 1, 2017·Current Developmental Disorders Reports·Karen E Seymour, Leslie Miller
Dec 12, 2018·NeuroImage. Clinical·Iselin MelukenKamilla Woznica Miskowiak
Mar 9, 2018·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Alexander SchneidtMichael Schönenberg

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Journal of the American Academy of Child and Adolescent Psychiatry
Jonathan PosnerBradley S Peterson
European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
Maja KobelIris-Katharina Penner
© 2021 Meta ULC. All rights reserved