PMID: 9181639May 1, 1997Paper

The attenuation of morphine-conditioned place preference following chronic mild stress is reversed by a CCKB receptor antagonist

Psychopharmacology
O ValverdeR Maldonado

Abstract

Chronic exposure to mild unpredictable stress has been found to abolish the acquisition of preference for a distinctive environment paired with morphine, whereas morphine induced conditioning place preference in non-stressed rats. Chronic treatment for 21 days with the tricyclic antidepressant imipramine reversed the motivational effects produced by chronic mild stress, and animals showed a place preference for the morphine-paired compartment. When the CCKB receptor antagonist PD-134,308 was co-administered with morphine in stressed animals during the conditioning period, the preference for the morphine-paired compartment was also re-established. The CCKB receptor antagonist given alone did not induce rewarding effects in this paradigm. These findings indicate that the administration of a CCKB receptor antagonist reversed the effects of chronic mild stress on opiate rewarding properties.

Citations

Jun 27, 2013·Cell and Tissue Research·Ove Wiborg
May 7, 2005·Neuroscience and Biobehavioral Reviews·Rick A Bevins, Joyce Besheer
Dec 21, 2000·Trends in Pharmacological Sciences·B P Roques
Jan 26, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J HarroL Oreland
Mar 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Klara FelszeghyDidier Pélaprat
Oct 16, 2014·Neural Regeneration Research·Lun Zheng, Xigeng Zheng
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Jan 3, 2006·Physiology & Behavior·Stephanie L BakerCatherine Bielajew
Jun 7, 2014·The International Journal of Neuropsychopharmacology·Patrícia VarelaJair Guilherme Santos-Junior
Dec 30, 2014·Frontiers in Psychiatry·Laurence LalannePierre-Eric Lutz
Jun 18, 2016·The American Journal of Drug and Alcohol Abuse·Enoch NgAlbert H C Wong
Mar 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Olga ValverdeRafael Maldonado
Dec 1, 2005·Neuroreport·Pouya Tahsili-FahadanAhmad Reza Dehpour

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