The attribution of incentive salience to a stimulus that signals an intravenous injection of cocaine

Behavioural Brain Research
Jason M UslanerTerry E Robinson

Abstract

A central premise of a number of theories of addiction is that discrete environmental stimuli repeatedly paired with drugs of abuse acquire incentive salience as a result of Pavlovian learning. There is, however, no unequivocal evidence supporting this assumption. Thus, we employed a Pavlovian conditioning procedure known to imbue non-drug reinforcers with incentive salience and extended it to study the effects of intravenous cocaine. Specifically, we examined whether a cue paired with intravenous cocaine administration would come to elicit approach towards it (sign-tracking), even if no behavioral response were required to receive the cue or drug. We found that when a cue was paired with intravenous cocaine delivery (but not when it was unpaired) rats came to approach and investigate the cue, and did so with increasing rapidity. We conclude that Pavlovian learning can imbue drug-paired cues with incentive salience, making them attractive and "wanted" stimuli. Delineating the neurobiological mechanisms responsible for this process will be important for understanding and treating drug addiction.

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Citations

Feb 1, 2007·Psychopharmacology·Christopher L Cunningham, Priya Patel
Mar 4, 2008·Psychopharmacology·Kent C Berridge, Morten L Kringelbach
Jun 12, 2013·Neuropharmacology·Terry E RobinsonBenjamin T Saunders
May 4, 2011·Behavioral Neuroscience·Tamara L Doremus-Fitzwater, Linda P Spear
Jul 3, 2007·Nature Neuroscience·Jeremy J DayRegina M Carelli
Oct 3, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christina M Gremel, Christopher L Cunningham
Oct 2, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shelly B FlagelHuda Akil
Apr 8, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin T Saunders, Terry E Robinson
Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jason M UslanerTerry E Robinson
Mar 25, 2009·Behavioural Pharmacology·Lakshmi Kelamangalath, John J Wagner
Aug 22, 2009·Behavioural Pharmacology·Gregory T Collins, James H Woods
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Terry E Robinson, Kent C Berridge
Apr 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jeremy J Day, Regina M Carelli
Jul 18, 2009·PLoS Computational Biology·Jun ZhangJ Wayne Aldridge
May 22, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen V Mahler, Kent C Berridge
Jun 25, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne-Noël Samaha
Jun 15, 2007·Substance Use & Misuse·David B Newlin, Kevin A Strubler
Jan 31, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Menton M DeweeseFrancesco Versace
Jan 18, 2011·Brain Research Bulletin·Martin E PumChristian P Müller
Jan 5, 2010·Biological Psychiatry·Benjamin T Saunders, Terry E Robinson
Oct 4, 2015·Neuroscience and Biobehavioral Reviews·Helen TibboelBram Van Bockstaele
Apr 11, 2012·The European Journal of Neuroscience·Kent C Berridge
Jan 23, 2010·The European Journal of Neuroscience·Christina M Gremel, Christopher L Cunningham
Mar 8, 2014·Addiction Biology·Heather B Madsen, Serge H Ahmed
Feb 27, 2013·Neuroscience and Biobehavioral Reviews·Benjamin T Saunders, Terry E Robinson

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