The atu and liu clusters are involved in the catabolic pathways for acyclic monoterpenes and leucine in Pseudomonas aeruginosa

Applied and Environmental Microbiology
J A AguilarJ Campos-García

Abstract

Evidence suggests that the Pseudomonas aeruginosa PAO1 gnyRDBHAL cluster, which is involved in acyclic isoprenoid degradation (A. L. Díaz-Pérez, N. A. Zavala-Hernández, C. Cervantes, and J. Campos-García, Appl. Environ. Microbiol. 70:5102-5110, 2004), corresponds to the liuRABCDE cluster (B. Hoschle, V. Gnau, and D. Jendrossek, Microbiology 151:3649-3656, 2005). A liu (leucine and isovalerate utilization) homolog cluster was found in the PAO1 genome and is related to the catabolism of acyclic monoterpenes of the citronellol family (AMTC); it was named the atu cluster (acyclic terpene utilization), consisting of the atuCDEF genes and lacking the hydroxymethyl-glutaryl-coenzyme A (CoA) lyase (HMG-CoA lyase) homolog. Mutagenesis of the atu and liu clusters showed that both are involved in AMTC and leucine catabolism by encoding the enzymes related to the geranyl-CoA and the 3-methylcrotonyl-CoA pathways, respectively. Intermediary metabolites of the acyclic monoterpene pathway, citronellic and geranic acids, were accumulated, and leucine degradation rates were affected in both atuF and liuD mutants. The alpha subunit of geranyl-CoA carboxylase and the alpha subunit of 3-methylcrotonyl-CoA carboxylase (alpha-MCCase), encoded by the...Continue Reading

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Citations

Aug 8, 2012·Cellular and Molecular Life Sciences : CMLS·Liang Tong
May 22, 2010·Applied Microbiology and Biotechnology·Karin Förster-Fromme, Dieter Jendrossek
Jan 30, 2013·Applied Microbiology and Biotechnology·Gustavo MolinaGláucia M Pastore
Jul 6, 2006·Applied and Environmental Microbiology·Karin Förster-FrommeDieter Jendrossek
Sep 30, 2008·Journal of Bacteriology·Alexey E KazakovMikhail S Gelfand
Aug 11, 2011·BMC Evolutionary Biology·Jonathan Lombard, David Moreira
May 26, 2015·Applied Microbiology and Biotechnology·Marleen OtzenDick B Janssen
Jan 19, 2010·Journal of Basic Microbiology·Ava ChattopadhyayDieter Jendrossek
Aug 1, 2014·Frontiers in Microbiology·Robert Marmulla, Jens Harder
Oct 27, 2006·FEMS Microbiology Letters·Karin Förster-Fromme, Dieter Jendrossek
Oct 11, 2008·Chembiochem : a European Journal of Chemical Biology·Helge B BodeRolf Müller
Jul 19, 2012·World Journal of Microbiology & Biotechnology·César Díaz-PérezJesús Campos-García
Jul 15, 2009·Molecular Biology Reports·Mauricio Chávez-AvilésJesús Campos-García

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