The audacity of proteomics: a chance to overcome current challenges in schizophrenia research

Expert Review of Proteomics
Nicoletta Baloyianni, George Th Tsangaris

Abstract

The evidence on the mechanisms underlying schizophrenia seems to support a series of divergent possibilities that may play a contributory role in the disease pathogenesis. Hypotheses regarding disease mechanisms range from structural and neurodevelopmental abnormalities to neurotransmitter deficits and genetic predisposition. Nevertheless, little progress has been made in the field of schizophrenia with respect to the key pathophysiological processes, and this is a fundamental barrier to identifying or predicting the therapeutic value of novel drug targets. All multi-omics approaches, including proteomics, would be perfectly suited to such a complex disease as a means of tackling the widening chasm between the aforementioned hypotheses. Proteomic studies have been performed in a variety of tissues and biological fluids, from post-mortem CNS tissue to cerebrospinal fluid and blood, and in recently generated mutant animal models with schizophrenia-like phenotypes. In this review, we present an overview of several proteomic studies in the field of schizophrenia research and discuss how proteomics could assist with identifying schizophrenia markers more efficiently, covering both clinical and basic research.

References

Jan 1, 1992·Clinical Neuropharmacology·D R WeinbergerD G Daniel
Sep 19, 1987·British Medical Journal·R M Murray, S W Lewis
Mar 1, 1994·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·W G RyanW E Grizzle
Oct 1, 1995·Schizophrenia Research·M T Tsuang, S V Faraone
Jan 20, 1998·The American Journal of Psychiatry·E Franzek, H Beckmann
Feb 14, 1998·European Journal of Endocrinology·C Kirkegaard, J Faber
Jun 20, 1998·Archives of General Psychiatry·R B ZipurskyD J Mikulis
Jan 23, 1999·Biological Psychiatry·L D Selemon, P S Goldman-Rakic
Jul 23, 1999·Schizophrenia Bulletin·J W NewcomerR Miller
Nov 26, 1999·European Psychiatry : the Journal of the Association of European Psychiatrists·H VolzH Sauer
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Jul 13, 2000·Archives of General Psychiatry·T H McGlashan, R E Hoffman
Jul 27, 2000·Annals of the New York Academy of Sciences·S Melov
Nov 30, 2000·Lancet·R E BanksP J Selby
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Sep 5, 2001·The American Journal of Psychiatry·D C Goff, J T Coyle
Nov 3, 2001·Science·A Carlsson
Dec 26, 2001·JAMA : the Journal of the American Medical Association·G H Brundtland
Feb 28, 2002·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Jul 2, 2002·The American Journal of Psychiatry·Mary CannonRobin M Murray
Sep 5, 2002·Nature Reviews. Drug Discovery·Emanuel F PetricoinLance A Liotta
Nov 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katerina ZavitsanouXu Feng Huang
Mar 28, 2003·Molecular Psychiatry·G M InnocentiJ Parnas
Jun 25, 2003·The Journal of Cell Biology·Jianxin BaoDavid A Talmage
Jul 30, 2003·Archives of General Psychiatry·N C Andreasen
Aug 28, 2003·Nature Cell Biology·Takashi NishimuraKozo Kaibuchi
Oct 31, 2003·The New England Journal of Medicine·Robert Freedman
Nov 12, 2003·Schizophrenia Bulletin·Victor Peralta, Manuel J Cuesta
Feb 3, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·N NiuJ L Sobell
Feb 20, 2004·The International Journal of Neuropsychopharmacology·Oliver D HowesRobin M Murray

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Citations

Jun 26, 2010·Neurochemical Research·Chenggang Zhang
Jul 27, 2010·Schizophrenia Research·Rajiv TandonMatcheri S Keshavan
Jan 1, 2015·NPJ Schizophrenia·Juliana M Nascimento, Daniel Martins-de-Souza
Jun 5, 2017·Journal of Psychiatric Research·Daniela Rodrigues-AmorimRoberto C Agís-Balboa

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