The auditory P50 response is normal in Alzheimer's disease when measured via a paired click paradigm

Electroencephalography and Clinical Neurophysiology
G FeinC van Dyke

Abstract

Recent findings of missing or markedly attenuated P50 (or P1) auditory ERPs in Alzheimer's disease (AD) patients suggest this may be a useful diagnostic and/or prognostic marker of AD cholinergic deficits. Those studies used repetitive 1/sec clicks. Given P50's long recovery time, all but the first click in that paradigm was presented during the recovery of the P50 generation system from the response to the prior click. We studied 8 AD patients and 17 elderly controls using a paradigm incorporating 7-8 sec intervals between clicks, which allows examination of P50 generation separate from P50 recovery. With the long inter-click interval, we identified P50 responses in most AD patients and controls, and found no difference in P50 amplitude between groups. These results suggest that if there is a P50 deficit in AD patients, it is the result of the accumulative effect of repetitive stimulation, rather than a primary deficit in P50 generation.

References

Nov 1, 1992·Biological Psychiatry·G Zouridakis, N N Boutros
Feb 15, 1992·Biological Psychiatry·K JergerG Fein
May 1, 1992·Neurology·J B GreenJ D Schwankhaus
Mar 1, 1991·Schizophrenia Research·R FreedmanH Nagamoto
Jan 1, 1990·Electroencephalography and Clinical Neurophysiology·A T CacaceJ R Wolpaw
Nov 1, 1991·Psychiatry Research·N N BoutrosG Zouridakis
Jan 15, 1990·Biological Psychiatry·P C Bickford-WimerR Freedman
Nov 1, 1986·Electroencephalography and Clinical Neurophysiology·R J Erwin, J S Buchwald
Sep 1, 1989·Electroencephalography and Clinical Neurophysiology·J S BuchwaldJ L Cummings
Jan 1, 1987·Schizophrenia Bulletin·R FreedmanR Franks

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Citations

Sep 15, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Inge KlinkenbergArjan Blokland
Jul 25, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E J Golob, A Starr
Jan 22, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Edward J GolobA Starr
Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E PekkonenT Erkinjuntti
Oct 4, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Iacopo CancelliMariarosaria Valente
Oct 4, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Paul ZarkowskiJoan Russo
Jun 1, 1997·Psychiatry and Clinical Neurosciences·C H ChenT Onitsuka
Jul 7, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R IrimajiriA Starr
Jul 15, 2011·Arquivos de neuro-psiquiatria·Jefferson BeckerJaderson Costa da Costa
Jun 20, 2008·Neurobiology of Aging·Christine ThomasMatthias Weisbrod
Feb 3, 2007·American Journal of Alzheimer's Disease and Other Dementias·Brandon A AllyAndrew E Budson

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