The Australian Multicenter Trial of Growth Hormone (GH) Treatment in GH-Deficient Adults

The Journal of Clinical Endocrinology and Metabolism
Ross C CuneoD Hurley

Abstract

GH treatment in adults with GH deficiency has numerous beneficial effects, but most studies have been small. We report the results of an Australian multicenter, randomized, double-blind, placebo-controlled trial of the effects of recombinant human GH treatment in adults with GH deficiency. GH deficiency was defined as a peak serum GH of < 5 mU/liter in response to insulin-induced hypoglycemia. Patients were randomly assigned to receive either GH (0.125 U/kg per week for 1 month and 0.25 U/kg per week for 5 months) or placebo. After 6 months, all patients received GH. The primary end points were biochemical responses, body composition, quality of life, and safety. One hundred sixty-six patients (72 females and 91 males) with a mean age of 40 +/- 1 yr (+/- SEM; range 17-67 yr) were recruited. Serum insulin-like growth factor-I (IGF-I) increased from a standard deviation score of -2.64 +/- 0.27 (range -8.8 +3.82; n = 78) to +1.08 +/- 2.87 (range -7.21 to +6.42) at 6 months in the GH/GH group; 38% of the whole group were above the age-specific reference range following treatment [17.6% and 68.9% with subnormal (< 2 SD) or normal (+/- 2 SD) pretreatment levels, respectively]. Fasting total cholesterol (P = 0.042) and low-density lip...Continue Reading

Citations

Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Tamara WexlerKaren K Miller
Jan 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Karen K MillerAnne Klibanski
Dec 15, 2007·Metabolism: Clinical and Experimental·Maria Claudia Peixoto CenciMario Vaisman
Nov 15, 2005·Endocrine Journal·Renee J FreedmanMichael T Collins
Feb 1, 2003·Experimental Gerontology·Gary R AndrewsDavid G Le Couteur

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