PMID: 8965116Apr 1, 1996Paper

The autoimmune reactivity to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis is potentially pathogenic: effect of copolymer 1 on MOG-induced disease

Journal of Neurology
A Ben-NunN Kerlero de Rosbo

Abstract

Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) characterized by primary demyelination, is believed to result from an autoimmune attack against myelin components. In view of their ability to induce experimental autoimmune encephalomyelitis (EAE), an animal model for MS, the quantitatively major malign proteins--myelin basic protein (MBP) and proteolipid protein (PLP)--have been extensively studied as the relevant primary antigens in MS, and therapeutic approaches have been targeted to counteract autoimmune reactivity to MBP and PLP. Accordingly, copolymer 1, a random synthetic amino acid copolymer crossreactive with MBP and highly protective against the induction of EAE with MBP or PLP, is not being extensively tested in clinical studies as a therapeutic agent for MS. However, increasing evidence suggests that autoimmune reactivity against other CNS-specific myelin proteins could also be involved in the pathogenesis of MS. In this context, we have demonstrated that peripheral blood lymphocytes from patients with MS respond predominantly to myelin oligodendrocyte glycoprotein (MOG) rather than to MBP or PLP, suggesting an important role for cell reactivity against MOG in the pathogenesis of MS....Continue Reading

References

Sep 1, 1992·Journal of Neuroscience Research·M V GardinierJ M Matthieu
Jan 1, 1991·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·V K KuchrooM B Lees
May 1, 1989·Journal of Neuroimmunology·N J ScoldingD A Compston
Jan 1, 1987·The Journal of Immunology : Official Journal of the American Association of Immunologists·J SatohT Tabira
Aug 1, 1971·European Journal of Immunology·D TeitelbaumM Sela
Sep 1, 1984·Journal of Neuroimmunology·C LinningtonP L Woodhams
Jan 1, 1993·Schweizer Archiv für Neurologie und Psychiatrie = Archives suisses de neurologie et de psychiatrie = Archivio svizzero di neurologia e psichiatria : offizielles Organ der Schweizerischen Neurologischen Gesellschaft und der SchweizerischenGesellschaft für ·D BurgerN Kerlero De Rosbo
Nov 1, 1993·Journal of Neurochemistry·D BurgerN Kerlero de Rosbo
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D Pham-DinhA Dautigny

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Citations

Feb 21, 2004·Journal of Neuroimmunology·Stefan JungKlaus Toyka
Apr 21, 1998·European Journal of Pharmacology·Q LiC T Bever
May 3, 2003·Pharmacology & Therapeutics·Suhayl Dhib-Jalbut
Apr 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M SchmiedD A Hafler
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·O NeuhausR Hohlfeld
Aug 9, 2003·Journal of Neurotrauma·Jonathan KipnisMichal Schwartz
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Hohlfeld
Jan 22, 2005·Annual Review of Medicine·Jingwu Zhang, George Hutton
Mar 23, 2012·Journal of Neuroinflammation·Yael Friedman-LeviRuth Gabizon
Dec 11, 2013·Clinical & Developmental Immunology·Masha Fridkis-Hareli
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·H SchoriM Schwartz
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·H L Weiner
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jian HongJingwu Z Zhang
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J KipnisM Schwartz
Dec 17, 2015·Journal of the Neurological Sciences·James AndersonRichard Sachleben
May 14, 2014·The American Journal of Pathology·Stefan BittnerSven G Meuth
Jul 17, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Y JeeT L Vollmer
Jul 14, 2007·CNS Drug Reviews·Maddalena RuggieriMaria Trojano
Aug 8, 2006·Cellular Immunology·Mandy L Ford, Brian D Evavold
Aug 15, 2015·Annals of Clinical and Translational Neurology·Kati FridRuth Gabizon
Jul 19, 2016·Toxicology·Beata Dąbrowska-BoutaLidia Strużyńska
Jan 21, 2004·Journal of Molecular Recognition : JMR·Ruth Arnon, Michael Sela
Sep 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lori BlanchfieldBrian D Evavold
Oct 16, 2018·Multiple Sclerosis : Clinical and Laboratory Research·David John BurrowsArshad Majid
Feb 17, 2006·International Immunology·Youngheun JeeTimothy L Vollmer
Sep 11, 2001·Multiple Sclerosis : Clinical and Laboratory Research·M ChenS Dhib-Jalbut
Apr 26, 2001·Multiple Sclerosis : Clinical and Laboratory Research·S RaghebR Lisak
Jun 13, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daren R Ure, Moses Rodriguez
Apr 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asaf MadiIrun R Cohen

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