PMID: 7334814Dec 1, 1981Paper

The automated counting of beating rates in individual cultured heart cells

Journal of Pharmacological Methods
G A CollinsM J Walker

Abstract

The effect of drugs on the beating rate of cultured heart cells can be monitored in a number of ways. The simultaneous automated measurement of beating rates of a number of cells allows drug effects to be rapidly quantified. A photoresistive detector placed on a television image of a cell, when coupled to operational amplifiers, gives binary signals that can be processed by a microprocessor. On this basis, we have devised a system that is capable of simultaneously monitoring the individual beating of six single cultured heart cells. A microprocessor automatically processes data obtained under different experimental conditions and records it in suitable descriptive formats such as dose-response curves and double reciprocal plots.

References

Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·M J WalkerD V Godin
Jul 1, 1977·European Journal of Pharmacology·M J Walker
Feb 1, 1963·Experimental Cell Research·I HARARY, B FARLEY

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Citations

Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J J Sun, M J Walker

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