The autonomic neural mechanism of right ventricular outflow tract tachycardia

Autonomic Neuroscience : Basic & Clinical
Hung-Yu ChangShih-Ann Chen

Abstract

Ventricular tachycardia (VT) and ventricular premature complexes (VPCs) originating from the right ventricular outflow tract (RVOT) are generally considered as benign arrhythmias, with ECG morphology showing LBBB pattern and inferior axis. Pathogenic mechanisms in the genesis of RVOT VT/VPC remain largely unknown. We aimed to investigate the neural mechanism in RVOT ventricular arrhythmias in canine model. Twelve mongrel dogs (13.7 ± 1.3 kg, 5 male dogs) were studied through midline thoracotomies. High-frequency stimulation (HFS) was applied to the proximal pulmonary artery (PA) to induce RVOT VT/VPC. An EnSite Array and a mapping catheter were used for electroanatomical mapping. The RVOT and PA were surgically excised for immunohistochemistry studies, including tyrosine hydroxylase (TH) stain for sympathetic nerves and choline acetyltransferase (ChAT) stain for parasympathetic nerves. In nine (75%) out of twelve dogs, HFS of the proximal PA induced RVOT VT/VPC. The density of TH-positive nerves was significantly higher than that of ChAT-positive nerves (6803 ± 700 vs. 670 ± 252 μm2/mm2, p < 0.001). Furthermore, the density of TH-positive nerves was also significantly higher in the VT/VPC origin sites than that in the non-origi...Continue Reading

Citations

May 21, 2020·Trends in Cardiovascular Medicine·Antonis A ManolisAntonis S Manolis
Jul 3, 2021·Journal of Cardiovascular Development and Disease·Mathilde R RivaudBastiaan J Boukens
Nov 12, 2021·Journal of Cellular and Molecular Medicine·Shih-Yu HuangYi-Jen Chen
Nov 20, 2021·Journal of Cardiovascular Electrophysiology·Michael C WaightMagdi M Saba

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