PMID: 9438458Jan 23, 1998Paper

The AutoPap 300 QC System multicenter clinical trials for use in quality control rescreening of cervical smears: I. A prospective intended use study

Cancer
S F PattenS Moinuddin

Abstract

The AutoPap 300 QC System is an automated device for the analysis of conventionally prepared cervical cytology slides. The AutoPap System selects an enriched population of cases for human quality control (QC) review. The device assigns a score based on the likelihood that a slide is abnormal. Cases are selected for QC rescreening that have scores exceeding a preset threshold corresponding to approximately the top 10% (or greater) of scores. AutoPap false-negative detection, compared with a 10% random QC process, was tested in a 6-center clinical evaluation study. At each site, a block of up to 150 consecutive negative slides (including detected false-negative cases) were selected randomly daily. All slides were run on the AutoPap System and rescreened by cytotechnologists for truth determination. The false-negative cases included in the top 10% group selected by AutoPap System then were compared with false-negative detection by the random selection process. Fourteen thousand nine hundred fourteen cases were analyzed. The AutoPap-enriched 10% quality control group contained false-negative cases at rates 3 to 5 times that of the random selection method (P < 0.01). The sensitivity for all false-negative cases was 35% and was 52% f...Continue Reading

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Citations

Feb 18, 2004·Computer Methods in Biomechanics and Biomedical Engineering·Karen L ReedThomas D Brown
Apr 3, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·H G WienerA Herbert
Jun 19, 2004·Pathology·F Joel W-M Leong, Anthony S Y Leong
Oct 17, 2003·Clinics in Laboratory Medicine·David C Wilbur
Oct 3, 2002·Diagnostic Cytopathology·Ann E Walts, Premi Thomas
Oct 4, 2016·International Journal of Cancer. Journal International Du Cancer·Mark SchiffmanNicolas Wentzensen
Feb 28, 2003·Advances in Anatomic Pathology·F Joel W-M Leong, Anthony S-Y Leong
Apr 1, 2018·Diagnostic Cytopathology·Michael J Thrall
Jun 20, 2002·Epidemiology·David C Wilbur, Mary K Norton
Feb 24, 2005·Clinical Obstetrics and Gynecology·Jennifer RussellChristopher M Zahn
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M H Stoler
Jul 8, 1999·Obstetrical & Gynecological Survey·O Abulafia, D M Sherer
Jan 2, 2003·Obstetrics and Gynecology Clinics of North America·Juan C Felix, Charles Amezcua

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