PMID: 9438459Jan 23, 1998Paper

The AutoPap 300 QC System multicenter clinical trials for use in quality control rescreening of cervical smears: II. Prospective and archival sensitivity studies

Cancer
S F PattenS Moinuddin

Abstract

The AutoPap 300 QC System is an automated device for the analysis of conventional cervical cytology slides. The AutoPap selects an enriched population of cases for quality control review. These studies evaluated the overall sensitivity of AutoPap device to a wider variety of cytologic abnormalities than could be analyzed in the prospective portion of the clinical trials. At five clinical trial sites, positive cases were selected from: 1) archives (historic sensitivity study) or 2) current positive cases (current archive sensitivity study). Cases were analyzed by the AutoPap System along with matched negative cases and stratified into detection deciles by instrument score for each diagnostic category. For the historic sensitivity study, the percentages of cases present within the top 10% instrument scores were as follows: atypical glandular cells of undetermined significance (AGUS): 33.7% (n = 243); low grade squamous intraepithelial lesion (LSIL): 57% (n = 412); high grade squamous intraepithelial lesion (HSIL): 81.6% (n = 385); and carcinoma: 77.7% (n = 139). For the current archive sensitivity study, the percentage of cases within the top 10% of instrument scores were as follows: atypical squamous cells of undetermined signif...Continue Reading

Citations

Jun 6, 2000·Journal of Women's Health & Gender-based Medicine·G H Eltabbakh, G D Eltabbakh
Feb 24, 2005·Clinical Obstetrics and Gynecology·Jennifer RussellChristopher M Zahn
Jun 20, 2002·Epidemiology·David C Wilbur, Mary K Norton
Oct 3, 2002·Diagnostic Cytopathology·Ann E Walts, Premi Thomas
Apr 13, 2017·Journal of Pathology Informatics·Kosuke OikawaMasahiko Kuroda
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M H Stoler
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M A Duggan
Apr 1, 2018·Diagnostic Cytopathology·Michael J Thrall
Jul 8, 1999·Obstetrical & Gynecological Survey·O Abulafia, D M Sherer
Jan 2, 2003·Obstetrics and Gynecology Clinics of North America·Juan C Felix, Charles Amezcua
Oct 17, 2003·Clinics in Laboratory Medicine·David C Wilbur

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