The Autophagic Machinery in Enterovirus Infection

Viruses
Jeffrey K F LaiYoke Fun Chan

Abstract

The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68. They cause a wide variety of diseases, ranging from mild to severe life-threatening diseases. Currently, no effective vaccine is available against enteroviruses except for poliovirus. Enteroviruses subvert the autophagic machinery to benefit their assembly, maturation, and exit from host. Some enteroviruses spread between cells via a process described as autophagosome-mediated exit without lysis (AWOL). The early and late phases of autophagy are regulated through various lipids and their metabolizing enzymes. Some of these lipids and enzymes are specifically regulated by enteroviruses. In the present review, we summarize the current understanding of the regulation of autophagic machinery by enteroviruses, and provide updates on recent developments in this field.

References

Aug 1, 1993·Journal of Virology·L Pérez, L Carrasco
Oct 1, 1996·Journal of Virology·A SchlegelK Kirkegaard
Jun 1, 1997·Medical Microbiology and Immunology·H P GrunertH Zeichhardt
Oct 21, 1998·The Journal of General Virology·E M PonnurajE A Simoes
Mar 20, 2004·Nature Reviews. Microbiology·Karla KirkegaardWilliam T Jackson
May 12, 2005·PLoS Biology·William T JacksonKarla Kirkegaard
Jun 7, 2006·The Journal of Cell Biology·Shun-ichi YamashitaYasuyoshi Sakai
Jul 29, 2006·Autophagy·Eeva-Liisa Eskelinen
Nov 3, 2006·Journal of Virology·George A BelovEllie Ehrenfeld
Aug 3, 2007·Journal of Virology·Marianne Brabec-ZarubaRenate Fuchs
Sep 7, 2007·Journal of Virology·Matthew P Taylor, Karla Kirkegaard
Nov 17, 2007·Genes & Development·Noboru Mizushima
Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
Jul 4, 2008·Journal of Virology·Jerry WongHonglin Luo
May 15, 2009·Journal of Clinical Microbiology·Fan YangJin Qi
May 29, 2009·Journal of Medical Virology·Shu-Chen HuangHsiao-Sheng Liu
Oct 3, 2009·The Journal of Cell Biology·Anne Simonsen, Sharon A Tooze
Nov 21, 2009·Journal of Biomedical Science·Jing-Yi LinShin-Ru Shih
Jan 16, 2010·FEBS Letters·Chloe Burman, Nicholas T Ktistakis
Mar 2, 2010·FEBS Letters·Isabelle Vergne, Vojo Deretic
Apr 10, 2010·Nature Reviews. Molecular Cell Biology·Bart VanhaesebroeckBenoit Bilanges
Oct 5, 2010·American Journal of Respiratory and Critical Care Medicine·Patrick MalliaSebastian L Johnston
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Apr 15, 2011·Journal of Lipids·Keisuke Obara, Yoshinori Ohsumi
May 3, 2011·Cell Metabolism·Rajat Singh, Ana Maria Cuervo
Jul 15, 2011·Journal of Virology·Kathryn A Klein, William T Jackson
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Noboru MizushimaYoshinori Ohsumi
Mar 10, 2012·Sub-cellular Biochemistry·Alex Toker
Sep 1, 2012·Nature Reviews. Drug Discovery·David C RubinszteinBeth Levine
Sep 12, 2012·Autophagy·Daniel J KlionskyBrian Zuckerbraun

❮ Previous
Next ❯

Citations

Aug 2, 2019·Future Microbiology·Xingjian WenAnchun Cheng
Aug 16, 2019·Journal of Virology·Autumn C Holmes, Bert L Semler
Nov 10, 2018·Frontiers in Microbiology·Raquel Bello-Morales, José Antonio López-Guerrero
Jun 20, 2019·Journal of Biomedical Science·Collins Oduor Owino, Justin Jang Hann Chu
Aug 30, 2020·Nature Communications·Piero GiansantiFrank J M van Kuppeveld
Jun 1, 2017·International Journal of Molecular Medicine·Huan ChangZuocheng Yang
Nov 28, 2017·Archives of Virology·Yuanxing GuXiaoliang Li
Sep 26, 2020·Frontiers in Microbiology·Xinhong LiXiaoyue Chen
Apr 25, 2020·Frontiers in Microbiology·Anna MajerTimothy F Booth
Jan 20, 2017·Nature·Kevin L McKnight, Stanley M Lemon
Dec 10, 2020·Microorganisms·Sami SalmikangasVarpu Marjomäki
Nov 14, 2020·Expert Review of Anti-infective Therapy·Han Kang TeeYoke Fun Chan
May 8, 2021·Scientific Reports·Yong Wah TanJustin Jang Hann Chu
Jul 14, 2021·Scientific Reports·Michael F BodeNigel Mackman

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
transmission electron microscopy
lipidation

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.