The Autophagy Gene Atg16L1 is Necessary for Endometrial Decidualization

Arin K OestreichRamakrishna Kommagani


Uterine receptivity is critical for establishing and maintaining pregnancy. For the endometrium to become receptive, stromal cells must differentiate into decidual cells capable of secreting factors necessary for embryo survival and placental development. Although there are multiple reports of autophagy induction correlated with endometrial stromal cell (ESC) decidualization, the role of autophagy in decidualization has remained elusive. To determine the role of autophagy in decidualization, we utilized 2 genetic models carrying mutations to the autophagy gene Atg16L1. Although the hypomorphic Atg16L1 mouse was fertile and displayed proper decidualization, conditional knockout in the reproductive tract of female mice reduced fertility by decreasing the implantation rate. In the absence of Atg16L1, ESCs failed to properly decidualize and fewer blastocysts were able to implant. Additionally, small interfering RNA knock down of Atg16L1 was detrimental to the decidualization response of human ESCs. We conclude that Atg16L1 is necessary for decidualization, implantation, and overall fertility in mice. Furthermore, considering its requirement for human endometrial decidualization, these data suggest Atg16L1 may be a potential mediato...Continue Reading


Feb 1, 1975·Biology of Reproduction·S Schlafke, A C Enders
May 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·S TabanelliE Gurpide
Jan 1, 1986·Annals of the New York Academy of Sciences·A Psychoyos
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Aug 1, 1997·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M HudsonN A Mowat
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·B A Lessey
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wen-ge MaSudhansu K Dey
Feb 1, 2005·Genesis : the Journal of Genetics and Development·Selma M SoyalJohn P Lydon
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey
Jun 24, 2006·Current Opinion in Obstetrics & Gynecology·Bolarinde Ola, Tin-Chiu Li
Nov 17, 2007·Genes & Development·Noboru Mizushima
Jan 28, 2009·Fertility and Sterility·José BellverMarcos Meseguer
Dec 26, 2009·Current Opinion in Cell Biology·Zhifen Yang, Daniel J Klionsky
Apr 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher J Brewer, Adam H Balen
Sep 3, 2010·Nature Cell Biology·Zhifen Yang, Daniel J Klionsky
Nov 13, 2010·Human Reproduction·Barbara LukeUNKNOWN SART Writing Group
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Apr 23, 2011·Endocrinology·D Randall Armant
Aug 9, 2011·Molecular and Cellular Endocrinology·Michael J Large, Francesco J DeMayo
Nov 18, 2011·Biology of Reproduction·JongYeob ChoiDooSeok Choi
Jan 21, 2014·The Journal of Endocrinology·Soyoung ChoiHyunjung Jade Lim
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Dec 30, 2014·Reproductive Sciences·Laura AvaglianoAnna Maria Marconi
Jun 27, 2019·International Journal of Molecular Sciences·Ana Cecilia Mestre CitrinovitzAriane Germeyer

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Feb 15, 2021·Human Immunology·Akitoshi NakashimaShigeru Saito
Apr 21, 2021·Reproductive Sciences·Pooja PopliRamakrishna Kommagani
Jun 3, 2021·International Journal of Molecular Sciences·Diqi YangYi Ding

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