The average body surface area of adult cancer patients in the UK: a multicentre retrospective study.

PloS One
Joseph J SaccoPeter Clark

Abstract

The majority of chemotherapy drugs are dosed based on body surface area (BSA). No standard BSA values for patients being treated in the United Kingdom are available on which to base dose and cost calculations. We therefore retrospectively assessed the BSA of patients receiving chemotherapy treatment at three oncology centres in the UK between 1(st) January 2005 and 31(st) December 2005.A total of 3613 patients receiving chemotherapy for head and neck, ovarian, lung, upper GI/pancreas, breast or colorectal cancers were included. The overall mean BSA was 1.79 m(2) (95% CI 1.78-1.80) with a mean BSA for men of 1.91 m(2) (1.90-1.92) and 1.71 m(2) (1.70-1.72) for women. Results were consistent across the three centres. No significant differences were noted between treatment in the adjuvant or palliative setting in patients with breast or colorectal cancer. However, statistically significant, albeit small, differences were detected between some tumour groups.In view of the consistency of results between three geographically distinct UK cancer centres, we believe the results of this study may be generalised and used in future costings and budgeting for new chemotherapy agents in the UK.

References

May 1, 1991·Journal of Pharmaceutical Sciences·D A Noe
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·G PowisJ N Ingle
Oct 22, 1987·The New England Journal of Medicine·R D Mosteller
Aug 1, 1993·Journal of Clinical Pharmacology·D A RushingD A Tewksbury
Aug 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A FeliciA Sparreboom
Dec 19, 2002·Journal of the National Cancer Institute·Sharyn D BakerAlex Sparreboom
Apr 12, 2003·The Lancet Oncology·Peter LittlejohnsUNKNOWN UK National Institute for Clinical Excellence
Feb 27, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Michael Joseph DooleyMichael Michael
Jun 2, 2005·Nature Reviews. Cancer·Samir D UndeviaMark J Ratain
Sep 27, 2005·Lancet·Marco ColleoniUNKNOWN International Breast Cancer Study Group
Feb 20, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·S A Kaestner, G J Sewell
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alex SparreboomSharyn D Baker
Mar 22, 2014·Clinical Pharmacology and Therapeutics·S BinsR H J Mathijssen

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Citations

Apr 3, 2012·Advanced Drug Delivery Reviews·Matias RaumaGunnar Johanson
Jan 6, 2016·ACS Applied Materials & Interfaces·Stephanie H TolbertDouglas A Loy
Sep 29, 2011·The Annals of Thoracic Surgery·Mehrdad SoleimaniMark B Ratcliffe
Aug 15, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Tatsunori TaniguchiYasushi Sakata
May 15, 2015·International Journal of Cardiology·Liyuan PengGang Wang
Oct 1, 2010·Pigment Cell & Melanoma Research·Angela M Gomez GarciaFrank L Meyskens
Oct 19, 2016·Clinical Physiology and Functional Imaging·Sille Mølvig HenriksenJens Børglum
Jun 28, 2014·Archives of Environmental & Occupational Health·Roh Allah ParvariSomayeh Farhang Dehghan
Dec 11, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yucel AltundalWilfred Ngwa
Mar 25, 2014·Dose-response : a Publication of International Hormesis Society·Rehana K Leak
Jul 25, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K LienU Emmenegger
Jun 22, 2016·Scientific Reports·Grzegorz RedlarskiMarek Krawczuk
Feb 1, 2017·Journal of Pharmaceutical Sciences·Alyssa M LarsonAlexander M Klibanov
Jan 31, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Sara WestrømRoy H Larsen
May 10, 2018·British Journal of Haematology·Ciara L Freeman, Laurie H Sehn
Aug 3, 2017·Pediatric Blood & Cancer·Robin Q H KloosInge M van der Sluis
Aug 19, 2017·Sexually Transmitted Infections·Lukas WestfechtelAlexander Nast
Apr 30, 2016·The Cochrane Database of Systematic Reviews·Lise J EstcourtEdwin Massey
Nov 15, 2018·Chembiochem : a European Journal of Chemical Biology·Vincent HuynhRyan G Wylie
May 4, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kristin M SheffieldAmine Ale-Ali
Mar 5, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Bryan DoAmber Rexwinkle
Feb 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ali McBrideKeith Stockerl-Goldstein
Apr 21, 2019·CPT: Pharmacometrics & Systems Pharmacology·Benjamin K SchneiderJonathan P Mochel
Jul 28, 2018·Nanotechnology·Sajad Yazdani, Michael Thompson Pettes

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