The aversive effect of acetaldehyde on alcohol drinking behavior in the rat

Alcoholism, Clinical and Experimental Research
C J Eriksson

Abstract

There are a number of indications suggesting that acetaldehyde (AcH) is one factor affecting the alcohol drinking behavior in laboratory animals. In the present study, the voluntary alcohol consumption in a free-choice situation was recorded in 17 females Sprague-Dawley rats fed with two different diets. The first diet (commercial Astra-Ewos, Sweden) caused significantly (p less than 0.001) higher blood AcH concentrations after oral alcohol administration and lower alcohol preferences (alcohol intake as percentage of total fluid intake) than the other diet (prepared at the Alko laboratories). With the Alko diet, the individual preference values correlated negatively with the blood AcH concentrations (p less than 0.01) and positively with the liver aldehyde dehydrogenase activities (p less than 0.05). Hepatic alcohol oxidation rate was found to correlate positively with the AcH concentrations from perfused livers (p less than 0.05) and negatively with the alcohol preferences (p less than 0.05), Alko diet). The results are discussed considering a possible biphasic relation between the AcH metabolism and alcohol drinking behavior.

References

May 15, 1977·Analytical Biochemistry·C J ErikssonO A Forsander
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Citations

Jul 1, 1993·Biological Psychiatry·T L WallC L Ehlers
Jan 1, 1981·Pharmacology, Biochemistry, and Behavior·K InoueK O Lindros
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·J D Sinclair, K O Lindros
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·J W Unwin, P V Taberner
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·W M KeungB L Vallee
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·R D Myers, J A Ewing
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·C J Eriksson, R A Deitrich
May 1, 1985·Alcoholism, Clinical and Experimental Research·C G Sanny
Aug 10, 2011·Neuroscience and Biobehavioral Reviews·Mercè CorreaElio Acquas
Jan 1, 1985·Social Biology·J R Wilson
Aug 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·R A Meisch

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