PMID: 7542303Jan 1, 1994Paper

The B cell antigen receptor complex: mechanisms and implications of tyrosine kinase activation

Immunologic Research
J TsengM R Clark

Abstract

The B cell receptor is a multimeric receptor complex whose constituent chains appear to mediate distinct and possibly interrelated functions. In this review we have focused on how one chain, immunoglobulin (Ig)-alpha, may function to activate tyrosine kinases and the consequences of that activation. The cytoplasmic domain of Ig-alpha contains a consensus sequence, the antigen recognition homology 1 (ARH 1) motif, which is found in Ig-beta and other antigen recognition receptor associated chains. We argue that this conserved structure reflects an underlying conserved mechanism of secondary effector activation. Our data also indicates that the specificity of each motif (i.e., the elements which restrict secondary effector binding to particular motifs) is encoded within divergent sequences found in each ARH 1 motif. In the particular case of kinase activation by Ig-alpha, the subsequent phosphorylation of multiple tyrosines on Ig-alpha, Ig-beta, CD19, CD22 and possibly other functionally related chains form recruitment sites for a myriad of secondary signal transducers. In this model, proximal tyrosine kinases and phosphatases do not function so much to mediate the linear transfer of information as to establish and modulate an int...Continue Reading

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Citations

Jul 17, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SiepertB Sawitzki
Oct 28, 2008·Cellular Signalling·Máté MausGabriella Sármay
Feb 26, 1999·The Journal of Cell Biology·D G StupackD A Cheresh
Mar 18, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James P MaloneyJorge Di Paola

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