PMID: 2497040May 1, 1989Paper

The B cell repertoire

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
C J Paige, G E Wu

Abstract

The hallmark of the immune system is its ability to produce a seemingly infinite variety of antigen-binding receptors. This is made possible by molecular and cellular mechanisms uniquely suited to continuously generate a large number of individual receptor molecules and to select some for further expansion. The well-studied genetic rearrangement that results in the juxtaposition of germ line-encoded variable, diversity, and joining elements remains the foundation for diversification on which the repertoire is built. Many of the rules that regulate this phenomenon have been described, although the underlying enzymatic machinery responsible for these events remains to be elucidated. Recent progress in categorizing the immunoglobulin heavy-chain variable region genes into families as well as studies establishing their utilization in both fetal and adult life is helping to further refine these rules. Subsequent cellular interactions 1) permit the discriminant expansion of clones expressing relevant antibody molecules, 2) allow the active affinity alterations needed for effective ongoing immune responses, and 3) limit the potential deleterious effect of autoreactive cells.

Citations

Apr 17, 2012·Immunological Reviews·Tyani D Chan, Robert Brink
Nov 19, 2013·FEBS Letters·Yael Weiss-Ottolenghi, Jonathan M Gershoni
Aug 20, 2016·Scientific Reports·Franz J J RiederChristoph Steininger
Jul 23, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jordan D DimitrovSebastien Lacroix-Desmazes
Oct 16, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K V Rao

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