The bacterial community and local lymphocyte response are markedly different in patients with recurrent tonsillitis compared to obstructive sleep apnoea

International Journal of Pediatric Otorhinolaryngology
James JohnstonRichard G Douglas

Abstract

Obstructive sleep apnea (OSA) is now a more common indication for tonsillectomy than recurrent tonsillitis (RT) [1,2]. Few studies have addressed possible differences in pathogenesis between these two conditions. Children with RT and OSA are often being treated in the community with multiple courses of antibiotics before surgery. Current understanding of the role of bacteria in disorders of the tonsils is mainly based on the culture of tonsil swabs. Swab cultures reflect only a very small fraction of the bacteria present on the mucosal surface and may not represent the bacterial communities within the tonsil crypts [3,4]. This study aimed to evaluate the local lymphocyte response and associations with bacterial community composition using molecular techniques of the tonsils removed from children for RT or OSA. The palatine tonsils were removed by extracapsular dissection from 24 patients with age range one to ten years, 14 of whom had RT and 10 had OSA. The fixed tonsil tissues were evaluated for bacteria by Gram-staining and presence of connective tissue by safranin staining. B lymphocytes and T lymphocytes were also measured immunohistochemically. Finally, previously published bacterial community data for this cohort were rea...Continue Reading

Citations

Aug 29, 2019·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Martín E Marcano-AcuñaPilar Codoñer-Franch
Jul 28, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·James JohnstonMurali Mahadevan
Jun 30, 2019·Pathogens·Fiona J RadcliffJohn D Fraser
Mar 12, 2021·Sleep·Yi CaiAndrew N Goldberg
Nov 13, 2020·Clinical and Experimental Otorhinolaryngology·Kyung Soo Kim, Hyun Jin Min
May 18, 2021·Frontiers in Immunology·Lindybeth Sarmiento VarónEloísa I Arana
Aug 10, 2021·Oncoimmunology·Angelina De MartinBurkhard Ludewig
Aug 26, 2021·World Journal of Otorhinolaryngology - Head and Neck Surgery·Alexandra ArambulaLaura Neff

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