The bacterial LexA transcriptional repressor

Cellular and Molecular Life Sciences : CMLS
M ButalaS J W Busby

Abstract

Bacteria respond to DNA damage by mounting a coordinated cellular response, governed by the RecA and LexA proteins. In Escherichia coli, RecA stimulates cleavage of the LexA repressor, inducing more than 40 genes that comprise the SOS global regulatory network. The SOS response is widespread among bacteria and exhibits considerable variation in its composition and regulation. In some well-characterised pathogens, induction of the SOS response modulates the evolution and dissemination of drug resistance, as well as synthesis, secretion and dissemination of the virulence. In this review, we discuss the structure of LexA protein, particularly with respect to distinct conformations that enable repression of SOS genes via specific DNA binding or repressor cleavage during the response to DNA damage. These may provide new starting points in the battle against the emergence of bacterial pathogens and the spread of drug resistance among them.

Citations

Aug 13, 2010·Nature·Adrianna P P ZhangPhoebe A Rice
Sep 12, 2013·Bioinformatics·Angela D WilkinsOlivier Lichtarge
Aug 24, 2013·Nucleic Acids Research·Lidija KovačičMatej Butala
Sep 9, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Anu V ChandranM Vijayan
Dec 21, 2010·Journal of Bacteriology·Xavier CharpentierHoward A Shuman
Sep 6, 2011·Journal of Bacteriology·Nadine FornelosJacques Mahillon
May 29, 2010·Microbiology and Molecular Biology Reviews : MMBR·Andrew RobinsonNicholas E Dixon
Apr 2, 2013·Canadian Journal of Microbiology·James L SmithGeorge C Paoli
Feb 9, 2013·Canadian Journal of Microbiology·Elena B M Breidenstein, Robert E W Hancock
Feb 13, 2009·BMC Bioinformatics·Ivan Erill, Michael C O'Neill
Oct 6, 2010·BMC Genomics·Shan LiZhengchang Su
Nov 17, 2012·BMC Genomics·Philippe OrtetMohamed Barakat
Oct 24, 2013·BMC Genomics·Alexey Y GorbachevVadim M Govorun
Dec 17, 2009·RNA·Susan E Wurster, L James Maher
Jul 24, 2012·Genes & Genetic Systems·Tetsuya MoriMasahiro Tatsumi Akiyama
Mar 12, 2010·PLoS Genetics·Natalie C FonvilleSusan M Rosenberg
Jun 22, 2012·PloS One·Robert ManasherobStanley N Cohen
Nov 19, 2013·PLoS Pathogens·Darja Žgur-Bertok
Aug 11, 2010·Genetics·Barret D PfeifferGerald M Rubin
Jan 11, 2013·Viruses·Paul ShkilnyjGerald B Koudelka
Jan 25, 2014·International Journal of Medical Microbiology : IJMM·Dorte FreesHanne Ingmer
Apr 10, 2014·BMC Microbiology·Beata M WalterMatej Butala
Aug 13, 2014·Nucleic Acids Research·Cai Chen, Ralf Bundschuh
Jul 23, 2014·Archives of Microbiology·Lusine GhazaryanOsnat Gillor
Aug 12, 2014·Nucleic Acids Research·Ruth SingerDaniel A Chamovitz
Feb 26, 2016·Frontiers in Microbiology·Transito Garcia-GarciaMarie-Françoise Noirot-Gros
Oct 21, 2015·Photochemistry and Photobiology·Ann Ganesan, Philip Hanawalt
Dec 11, 2014·Proceedings of the National Academy of Sciences of the United States of America·Julia BosRobert H Austin
Jan 15, 2016·Nucleic Acids Research·Luciane Schons-FonsecaRenata M A da Costa

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