PMID: 2120409Aug 1, 1990Paper

The bactericidal activity of a deuteroporphyrin-hemin mixture on gram-positive bacteria. A microbiological and spectroscopic study

Journal of Photochemistry and Photobiology. B, Biology
Z MalikB Ehrenberg

Abstract

The combined antibacterial activity of various porphyrins with hemin on Gram-positive bacteria was studied. Protoporphyrin, hematoporphyrin derivative and deuteroporphyrin show only a marginal inhibitory effect in the dark. However, hemin has a strong cytotoxic effect which is independent of illumination and is equally strong in the dark. The disadvantage of hemin treatment is that it is temporary. In this study, we have demonstrated that a combination of deuteroporphyrin and hemin has a unique cytotoxic activity on Staphylococcus aureus, Streptococcus faecalis and Bacillus cereus. The effect of the combined compound is stronger than that of the separate constituents, and is as strong in the dark as in the light. Only 0.005% of the initial S. aureus population survive after a 2 h treatment. Absorption and fluorescence spectra of hemin-deuteroporphyrin mixtures in water and liposomes suggest the formation of a species with spectroscopic properties which are different from those of the two constituents.

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Citations

Oct 14, 2009·Clinical Oral Investigations·Andreas RühlingThomas Kocher
Nov 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·G ValdugaG Jori
May 10, 2005·Journal of Photochemistry and Photobiology. B, Biology·Peter Meisel, Thomas Kocher
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael R Hamblin, Tayyaba Hasan
Jan 1, 1992·Photochemistry and Photobiology·Y NitzanB Ehrenberg
Dec 17, 2009·Photochemistry and Photobiology·Rivka CahanYeshayahu Nitzan
May 25, 2004·Antimicrobial Agents and Chemotherapy·Faten GadMichael R Hamblin
Sep 2, 2008·Canadian Journal of Physiology and Pharmacology·Robert T KinobeKanji Nakatsu
Nov 21, 2012·Photochemistry and Photobiology·Faina NakonechnyMarina Nisnevitch
Dec 8, 2010·Periodontology 2000·Nikolaos S Soukos, J Max Goodson
Feb 15, 2001·Expert Opinion on Investigational Drugs·I StojiljkovicV Kumar
Oct 15, 2011·Journal of Dentistry·Thiago C SilvaDong Mei Deng
Mar 30, 2017·ACS Chemical Biology·Ting-Yi WangJean-Philippe Pellois
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·N S SoukosT Hasan
Apr 16, 1998·FEMS Immunology and Medical Microbiology·A OrensteinY Nitzan

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