The bactericidal activity of DR-3355, an optically active isomer of ofloxacin.

Journal of Medical Microbiology
C S Lewin, S G Amyes

Abstract

The bactericidal activity of compound DR-3355, an optically active isomer of ofloxacin, was measured against Escherichia coli, Staphylococcus aureus and S. epidermidis, in nutrient broth and in phosphate-buffered saline. DR-3355 was found to be approximately twice as active as ofloxacin in terms of the concentration at which maximum bacterial kill was achieved. Hence it appears that DR-3355 is twice as active as ofloxacin not only in terms of its ability to inhibit bacterial multiplication but also in its ability to kill bacteria. DR-3355 was found to be active against non-dividing bacteria and did not require either active RNA or protein biosynthesis in order to kill bacteria.

Citations

Apr 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C S LewinJ T Smith
Nov 1, 1990·The Journal of Pharmacy and Pharmacology·C S LewinS G Amyes
Jul 1, 1991·The Journal of Pharmacy and Pharmacology·C S LewinJ T Smith
Sep 22, 2010·Antimicrobial Agents and Chemotherapy·Muhammad MalikRobert J Kerns
May 20, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S NguyenE Senneville
Aug 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A SorianoJ Mensa
Sep 18, 1997·Microbiology and Molecular Biology Reviews : MMBR·K Drlica, X Zhao

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