The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles

Cell Communication and Signaling : CCS
Pan WuYuhong Li

Abstract

The periodic growth of hair follicles is regulated by the balance of activators and inhibitors. The BMP signaling pathway plays an important role during hair follicle regeneration, but the exact BMP protein that controls this process has not been revealed. The expression of BMP6 was determined via in situ hybridization and immunofluorescence. The in vivo effect of BMP6 overexpression was studied by using a previously established adenovirus injection model. The hair follicle regeneration was assessed by gross observation, H&E staining and 5-bromo-2-deoxyuridine (BrdU) tracing. The expression patterns of BMP6 signaling and Wnt10b signaling in both AdBMP6-treated and AdWnt10b-treated skins were determined by in situ hybridization and immunofluorescence. BMP6 was expressed differently in the stages of hair follicle cycle. The telogen-anagen transition of hair follicles was inhibited by adenovirus-mediated overexpression of BMP6. In the in vivo model, the BMP6 signaling was inhibited by Wnt10b and the Wnt10b signaling was inhibited by BMP6. The activation of hair follicle stem cells (HFSCs) was also competitively regulated by Wnt10b and BMP6. Combined with previously reported data of Wnt10b, our findings indicate that BMP6 and Wnt10...Continue Reading

References

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Citations

Jun 14, 2020·Integrative and Comparative Biology·C Darrin HulseyGareth J Fraser
Jul 16, 2020·International Journal of Molecular Sciences·Bu Young Choi
Feb 18, 2021·Signal Transduction and Targeted Therapy·Shuaifei JiXiaobing Fu
Mar 27, 2021·EvoDevo·Tyler A SquareCraig T Miller
May 21, 2021·Advanced Materials·Giorgio ContaJun Chen
May 28, 2021·Clinical, Cosmetic and Investigational Dermatology·Xu ZhaiDaping Yang

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Methods Mentioned

BETA
RNA-seq
transgenic

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