The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease

The Journal of Biological Chemistry
Yue ZhaoChao-Jun Li

Abstract

Protein prenylation is an essential posttranslational modification and includes protein farnesylation and geranylgeranylation using farnesyl diphosphate or geranylgeranyl diphosphate as substrates, respectively. Geranylgeranyl diphosphate synthase is a branch point enzyme in the mevalonate pathway that affects the ratio of farnesyl diphosphate to geranylgeranyl diphosphate. Abnormal geranylgeranyl diphosphate synthase expression and activity can therefore disrupt the balance of farnesylation and geranylgeranylation and alter the ratio between farnesylated and geranylgeranylated proteins. This change is associated with the progression of nonalcoholic fatty liver disease (NAFLD), a condition characterized by hepatic fat overload. Of note, differential accumulation of farnesylated and geranylgeranylated proteins has been associated with differential stages of NAFLD and NAFLD-associated liver fibrosis. In this review, we summarize key aspects of protein prenylation as well as advances that have uncovered the regulation of associated metabolic patterns and signaling pathways, such as Ras GTPase signaling, involved in NAFLD progression. Additionally, we discuss unique opportunities for targeting prenylation in NAFLD/hepatocellular ca...Continue Reading

References

Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J W JanssenC R Bartram
Mar 1, 1994·The Journal of Investigative Dermatology·N J BallJ P Hoeffler
Jan 1, 1996·Annual Review of Biochemistry·F L Zhang, P J Casey
Jun 1, 1997·Molecular and Cellular Biology·R G QiuM Symons
May 30, 1997·The Journal of Biological Chemistry·C A RowellA M Garcia
May 30, 1997·The Journal of Biological Chemistry·D B WhyteJ K Pai
Jan 19, 2000·Circulation·D J MaronM F Linton
Mar 14, 2000·Molecular and Cellular Biology·A ApolloniJ F Hancock
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·R BaronA Pradines
Aug 17, 2002·Genes & Development·Nesrin M HamadChristopher M Counter
Jan 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C S SolomonM L Goalstone
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Paul D ThompsonRichard H Karas
Sep 23, 2003·The American Journal of Gastroenterology·Stephen A HarrisonPaul H Hayashi
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Van CutsemD Von Hoff
May 18, 2004·The Journal of Clinical Investigation·Mitsuhiro WatanabeJohan Auwerx
Oct 2, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S RaoP A Palmer
Mar 8, 2005·Experimental Cell Research·Julien MazièresAnne Pradines
Mar 25, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga Chalasani
Mar 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Claire ArnaudFrançois Mach
Apr 20, 2005·Cancer Cell·Nieves MijimolleMariano Barbacid
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Arun J Sanyal
Feb 16, 2006·Current Cancer Drug Targets·Kelly M Swanson, Raymond J Hohl
Mar 7, 2006·Bioorganic & Medicinal Chemistry·Larry W ShullDavid F Wiemer
Dec 27, 2006·Free Radical Biology & Medicine·Shane MierschBulent Mutus
Jan 9, 2007·Biochemical and Biophysical Research Communications·Andrew J WiemerRaymond J Hohl
May 1, 2007·Clinical Biochemistry·Irina Buhaescu, Hassane Izzedine
May 4, 2007·The Journal of Clinical Investigation·Anna-Karin M SjogrenMartin O Bergo
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Dolores Perez-Sala
Jan 1, 1996·Trends in Endocrinology and Metabolism : TEM·C Weinberger
Nov 26, 2008·Nature Reviews. Cancer·Natalie Meyer, Linda Z Penn
Mar 20, 2009·Nature Chemical Biology·James L Hougland, Carol A Fierke
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson

❮ Previous
Next ❯

Citations

Jul 9, 2021·Journal of Medicinal Chemistry·Edyta Gendaszewska-DarmachKatarzyna M Błażewska

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.