The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues

Frontiers in Cell and Developmental Biology
Joshua D Webster, Domagoj Vucic

Abstract

Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in healthy organisms and in disease. TNF is involved in the development and proper functioning of the immune system by mediating cell survival and cell death inducing signaling. TNF stimulated signaling pathways are tightly regulated by a series of phosphorylation and ubiquitination events, which enable timely association of TNF receptors-associated intracellular signaling complexes. Disruption of these signaling events can disturb the balance and the composition of signaling complexes, potentially resulting in severe inflammatory diseases.

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Citations

Oct 1, 2020·Cell Death and Differentiation·Sara DominguezBaris Bingol
Jan 14, 2021·The EMBO Journal·Matthias Kist, Domagoj Vucic
Jun 3, 2021·International Journal of Molecular Sciences·Almerinda Di VenereGiampiero Mei
Jul 5, 2021·Trends in Immunology·Rajendra Karki, Thirumala-Devi Kanneganti
Aug 8, 2021·International Journal of Molecular Sciences·Chao-Yi WuJenn-Haung Lai
Sep 10, 2020·ACS Chemical Biology·Catia L PierottiGuillaume Lessene

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Methods Mentioned

BETA
ubiquitination
IEC
biopsies

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