The basal forebrain cholinergic system and object memory in the rat

Brain Research
N VnekL A Rothblat

Abstract

Rats with near complete destruction of basal forebrain cholinergic neurons from intracerebroventricular injections of 192 IgG-saporin were trained on object discrimination problems and then retrained two weeks later to measure retention. Despite dramatic reductions of acetylcholinesterase-positive fibers in hippocampus and neocortex, these animals did not differ from controls on an analysis of savings scores. Thus, the basal forebrain cholinergic system may serve functions that support non-spatial memory but are not specifically mnemonic in nature.

References

Jul 30, 1982·Science·R T BartusA S Lippa
Jun 8, 1995·Nature·A Björklund, S B Dunnett

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Citations

Aug 30, 2003·Behavioural Brain Research·Hermenegildo Sos-HinojosaMargarita Martí-Nicolovius
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C C Wrenn, R G Wiley
Jan 27, 2016·Neuroscience·Charles J VierckRonald G Wiley
Apr 2, 2013·Biological Psychiatry·Alessandra Bonito-OlivaGilberto Fisone
Jan 30, 2004·Learning & Memory·Giancarlo Pepeu, Maria Grazia Giovannini

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